2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid 2-((3R,6S,9R,12R,17aS)-9-((1H-吲哚-3-基)甲基)-6-异丁基-3-异丙基-1,4,7,10,13-五氧基十六氢-1H-吡咯[1,2-a][1,4,7,10,13]五氮杂环戊二烯基)乙酸
CAS 136553-81-6 MFCD00133204
化学结构图
SMILES: CC(C)[C@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC2=CNC3C=CC=CC2=3)NC(=O)[C@H](CC(C)C)NC1=O
化学属性
| Mol. Formula | C31H42N6O7 |
|---|---|
| Mol. Weight | 610.70 |
别名和识别编码
| Chemical Name | 2-((3R,6S,9R,12R,17As)-9-((1H-Indol-3-Yl)Methyl)-6-Isobutyl-3-Isopropyl-1,4,7,10,13-Pentaoxohexadecahydro-1H-Pyrrolo[1,2-A][1,4,7,10,13]Pentaazacyclopentadecin-12-Yl)Acetic Acid |
|---|---|
| MDL Number | MFCD00133204 |
| PubChem Substance ID | 24891595 |
| CAS Number | 136553-81-6 |
| Synonym | |
| Chemical Name Translation | 2-((3R,6S,9R,12R,17aS)-9-((1H-吲哚-3-基)甲基)-6-异丁基-3-异丙基-1,4,7,10,13-五氧基十六氢-1H-吡咯[1,2-a][1,4,7,10,13]五氮杂环戊二烯基)乙酸 |
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分类
- {SNA} Antagonists, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Endothelin - Receptor Antagonists, Endothelins, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
- {SNA} Antagonists,
- Antagonists, B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Endothelin - Receptor Antagonists, Endothelins, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Peptides and Proteins, Peptides for Cell Biology, Proteins and Derivatives
- {SNA} Antagonists,
相关文献及参考
- [2]. Sakamoto A, et al. Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists. J Biol Chem. 1993 Apr 25;268(12):8547-53.
- [3]. Zamora MA, et al. BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1993;9(4):429-433.
- [4]. Douglas SA, et al. BQ-123, a selective endothelin subtype A-receptor antagonist, lowers blood pressure in different rat models of hypertension. J Hypertens. 1994;12(5):561-567.
- [5]. Erdogan H et al. The protective effects of endothelin-A receptor antagonist BQ-123 in pentylenetetrazole-induced seizure in rats. Hum Exp Toxicol, 2014 Oct, 33(10):1008-16.
- Douglas, et al., Novel receptor antagonists welcome a new era in endothelin biology. Trends Pharmacol. Sci. 15 , 313, (1994) 摘要
- Morel, et al., The endothelin ET A receptor a
