CAS 9025-82-5 MFCD00131883-Phosphodiesterase 磷酸二酯酶I TAO{mole}

Phosphodiesterase 磷酸二酯酶I

CAS 9025-82-5 MFCD00131883

化学结构图

SMILES: CN(C)C1CCc2cc3nc(N)sc3cc2C1.CN(C)C1CCc2cc3sc(N)nc3cc2C1.CN(C)C1Cc2cc3nc(N)sc3cc2C1.CN(C)C1Cc2ccc3nc(N)sc3c2C1.CN(C)C1Cc2ccc3sc(N)nc3c2C1

别名和识别编码

MDL Number	MFCD00131883
CAS Number	9025-82-5
Synonym	5'-Exonuclease 5'-Exonuclease Oligonucleate 5'-nucleotidohydrolase E.C. 3.1.4.1 Hydrolases, Phosphoric Diester Oligonucleate 5'-nucleotidohydrolase Phosphodiesterase Phosphodiesterase I Phosphodiesterase I from Bothrops atrox Phosphodiesterases Phosphoric Diester Hydrolases 磷酸二脂酶I
EC Number	232-806-5
Chemical Name	Phosphodiesterase I from Bothrops atrox
Chemical Name Translation	磷酸二酯酶I
PubChem Substance ID	161498078
InChI	InChI=1S/2C13H17N3S.3C12H15N3S/c1-16(2)10-4-3-8-7-12-11(6-9(8)5-10)15-13(14)17-12;1-16(2)10-4-3-8-6-11-12(7-9(8)5-10)17-13(14)15-11;1-15(2)9-3-7-5-10-11(6-8(7)4-9)16-12(13)14-10;1-15(2)8-5-7-3-4-10-11(9(7)6-8)14-12(13)16-10;1-15(2)8-5-7-3-4-10-11(9(7)6-8)16-12(13)14-10/h26-7,10H,3-5H2,1-2H3,(H2,14,15);5-6,9H,3-4H2,1-2H3,(H2,13,14);23-4,8H,5-6H2,1-2H3,(H2,13,14)

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产品应用

Phosphodiesterase (PDE) is any enzyme that is used to breaks phosphodiester bonds. It is a membrane-bound glycoprotein that is used to catalyze the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is used in phosphodiesterase activation assays to hydrolyze AMP.

安全信息

WGK Germany1

RTECSSZ5999500

Storage condition 储存温度 -20°C

GHS Symbol

Precautionary statements

P233 Keep container tightly closed. ?保持容器密闭。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P302+P350
P304+P340
P342+P316
P403 Store in a well-ventilated place. 储存在通风良好的地方。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H300+H310+H330
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Signal word Danger

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Hazard Codes T+

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1960-
   Volume(issue)/page/year: 8,849,1967

其他信息

Venom exonuclease (Phosphodiesterase I) successively hydrolyzes 5'-mononucleotides from 3'-OH-terminated ribo- and deoxyribo-oligonucleotides. The enzyme has an optimal pH range of 9.8-10.4 and a molecular weight of 115 kDa. Phosphodiesterase is inhibited by reducing agents such as glutathione, cysteine and ascorbic acids. It is completely inhibited by 5mM EDTA while ATP, ADP and AMP are partial inhibitors. The enzyme has an absolute requirement for Mg2+.