4-[Hydroxy-[4-(2-methylpropyl)phenyl]methylidene]-1-(6-methylpyridazin-3-yl)-5-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,3-dione;4-[hydroxy-(4-propan-2-ylphenyl)methylidene]-1-(6-methoxypyridazin-3-yl)-5-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,3-dione;4-[hydroxy-(4-propan-2-ylphenyl)methylidene]-1-(1-methyl-2-oxopyridin-3-yl)-5-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,3-dione;4-[hydroxy-(4-propan-2-ylphenyl)methylidene]-1-(5-methylpyrazin-2-yl)-5-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,3-dione;4-[hydroxy-(4-propan-2-ylphenyl)methylidene]-1-(6-methylpyridazin-3-yl)-5-(4-methylsulfonylphenyl)pyrrolidine-2,3-dione 扁桃腈裂解酶 来源于杏仁

CAS 9024-43-5 MFCD00131572

化学结构图

9024-43-5
SMILES: CC(C)c1ccc(C(O)=C2C(=O)C(=O)N(c3cccn(C)c3=O)C2c2ccc(OC(F)(F)F)cc2)cc1.COc1ccc(N2C(=O)C(=O)C(=C(O)c3ccc(C(C)C)cc3)C2c2ccc(OC(F)(F)F)cc2)nn1.Cc1ccc(N2C(=O)C(=O)C(=C(O)c3ccc(C(C)C)cc3)C2c2ccc(S(C)(=O)=O)cc2)nn1.Cc1ccc(N2C(=O)C(=O)C(=C(O)c3ccc(CC(C)C)cc3)C2c2ccc(OC(F)(F)F)cc2)nn1.Cc1cnc(N2C(=O)C(=O)C(=C(O)c3ccc(C(C)C)cc3)C2c2ccc(OC(F)(F)F)cc2)cn1

别名和识别编码

Synonym Acetone cyanohydrin lyase Mandelonitrile lyase Mandelonitrile benzaldehyde-lyase Oxynitrilase from bitter almonds 扁桃腈裂解酶 来源于杏仁
MDL NumberMFCD00131572
CAS Number9024-43-5
EC Number232-780-5
Chemical Name Translation扁桃腈裂解酶 来源于杏仁
Chemical Name(R)-Oxynitrilase
PubChem Substance ID160158195
InChIInChI=1S/C27H24F3N3O4.C27H23F3N2O5.C26H22F3N3O5.C26H22F3N3O4.C26H25N3O5S/c1-15(2)14-17-5-7-19(8-6-17)24(34)22-23(18-9-11-20(12-10-18)37-27(28,29)30)33(26(36)25(22)35)21-13-4-16(3)31-32-21;1-15(2)16-6-8-18(9-7-16)23(33)21-22(17-10-12-19(13-11-17)37-27(28,29)30)32(26(36)24(21)34)20-5-4-14-31(3)25(20)35;1-14(2)15-4-6-17(7-5-15)23(33)21-22(16-8-10-18(11-9-16)37-26(27,28)29)32(25(35)24(21)34)19-12-13-20(36-3)31-30-19;1-14(2)16-4-6-18(7-5-16)23(33)21-22(17-8-10-19(11-9-17)36-26(27,28)29)32(25(35)24(21)34)20-13-30-15(3)12-31-20;1-15(2)17-6-8-19(9-7-17)24(30)22-23(18-10-12-20(13-11-18)35(4,33)34)29(26(32)25(22)31)21-14-5-16(3)27-28-21/h4-13,15,23,34H,14H2,1-3H3;4-15,22,33H,1-3H3;4-14,22,33H,1-3H3;4-14,22,33H,1-3H3;5-15,23,30H,1-4H3
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分类

  • {SNA} 4.1.x.x C-C bonds, 4.x.x.x Lyases, Biochemicals and Reagents, Cell Biology, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, General Metabolic Enzymes, General Metab
  • {SNA} 4.1.x.x C-C bonds, 4.x.x.x Lyases, Biochemicals and Reagents, Enzyme Class Index, General Metabolic Enzymes, General Metabolic Enzymes I-Z, 代谢组学, 细胞生物学, 酶、抑制剂和底物
  • 4.1.x.x C-C bonds, 4.x.x.x Lyases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, General Metabolic Enzymes, General Metabolic Enzymes I-Z, Metabolomics
  • {SNA} 4.1.x.x C-C bonds,

相关文献及参考

  • Petrounia, I.P., et al, Transient Inactivation of Almond Mandelonitrile Lyase by 3-Methyleneoxindole: A Photooxidation Product of the Natural Plant Hormone Indole-3-Acetic Acid. Biochemistry 33(10) , 2891-2899, (1994)
  • Glieder, A., et al, Comprehensive Step-by-Step Engineering of an (R)-Hydroxynitrile Lyase for Large-Scale Asymmetric Synthesis. Angew. Chem. Int. Ed. Engl. 42(39) , 4815-4818, (2003)
  • Pscheidt, B., et al, Screening hydroxynitrile lyases for (R)-pantolactone synthesis. J. Mol. Catal., B Enzym. 52(53) , 183-188, (2008)

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Hazard Codes Xn
GHS Symbol
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P352
  • P304+P340
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P333+P317
  • P342+P311
  • P342+P316
  • P362+P364
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S22 Do not breathe dust 不要吸入粉尘；
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
Risk Statements
  • R42/43

系列性分类

  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. General Metabolic Enzymes - Metabolomics
  4. General Metabolic Enzymes I-Z - General Metabolic Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Application Index - Enzymes, Inhibitors, and Substrates
  5. Organic Synthesis and Immobilized Enzymes - Application Index
  6. Organic Synthesis - Organic Synthesis and Immobilized Enzymes
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Class Index - Enzymes, Inhibitors, and Substrates
  5. 4.x.x.x Lyases - Enzyme Class Index
  6. 4.1.x.x C-C bonds - 4.x.x.x Lyases

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