Filipin complex from Streptomyces filipinensis
CAS 11078-21-0 MFCD00131073
化学结构图
SMILES:
别名和识别编码
| MDL Number | MFCD00131073 |
|---|---|
| CAS Number | 11078-21-0 |
| Chemical Name | Filipin complex from Streptomyces filipinensis |
| Synonym | Filipin complex 14-Deoxylagosin Filimirasin Filmirisin |
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分类
- Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Application Index, Biochemicals and Reagents, Chemical Structure Class, Enzymes, Inhibitors, and Substrates, Filipin complex, Interferes with Cell Membrane Permeability (Ionophores), Macrolides, Mechanism of Action, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives, Serum Proteins, Serum Proteins and Related Enzymes, Spectrum of Activity
- {SNA} Antibiotics A to Z,
- {SA} Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antifungal, Application Index, Biochemicals and Reagents,
- {SNA} Antibi
相关文献及参考
- 1. Kawasaki, S., et al., Sterol control of the phosphatidylethanolamine-phosphatidylcholine conversion in the yeast mutant GL7. Proc. Natl. Acad. Sci. U. S. A. 82 , 5715-9 , (1985) 摘要
- 2. Lopes, S.C., et al., Filipin orientation revealed by linear dichroism. Implication for a model of action J. Am. Chem. Soc. 126 , 5396-5402, (2004) 摘要
- 3. Marella, M., et al., Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release. J. Biol. Chem. 277 , 3737-47, (2002) 摘要
- Halliday, G.M., et al., {alpha}-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease Brain 128 , 2654-64, (2005) 摘要
- Merck 14 ,4080
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,215,1980
