Aprotinin 抑肽酶
CAS 9087-70-1 MFCD00130541
化学结构图
SMILES: CCC(C)C1NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C2CSSCC3NC(=O)CNC(=O)CNC(=O)C(Cc4ccc(O)cc4)NC(=O)C(C(C)C)NC(=O)C(Cc4ccccc4)NC(=O)C(C(C)O)NC(=O)C(CCC(N)=O)NC(=O)C(CSSCC(NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(Cc4ccccc4)NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC3=O)C(=O)NC(CCSC)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)CSSCC(NC(=O)C(Cc3ccccc3)NC(=O)C(CC(=O)O)NC(=O)C3CCCN3C(=O)C(N)CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)N3CCCC3C(=O)N3CCCC3C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(C(C)O)C(=O)NCC(=O)N3CCCC3C(=O)N2)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(C)NC(=O)C(CC(N)=O)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)CC)NC1=O
化学属性
| Mol. Weight | 6511 |
|---|---|
| Mol. Formula | C284H432N84O79S7 |
别名和识别编码
| Synonym | Antilysin Aprotinin Aprotinin from Bovine Lung {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
|---|---|
| MDL Number | MFCD00130541 |
| CAS Number | 9087-70-1 |
| EC Number | 232-994-9 |
| Chemical Name | Aprotinin |
| Chemical Name Translation | 抑肽酶 |
| LabNetwork Molecule ID | LN01326291 |
| PubChem Substance ID | 22833874 |
| InChI | InChI=1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(414)322-149(14)230(398)326-168(62-35-39-98-285)234(402)319-146(11)227(395)314-132-215(385)324-181(113-141(3)4)247(415)354-199-137-452-453-138-200-263(431)336-179(97-112-448-20)242(410)331-176(70-48-107-311-284(304)305)244(412)363-226(154(19)372)274(442)358-197(233(401)316-129-212(382)312-130-213(383)318-151(16)278(446)447)135-449-451-139-201(355-253(421)186(117-157-57-31-25-32-58-157)344-256(424)195(127-220(393)394)350-267(435)204-72-50-109-366(204)275(443)167(289)61-43-102-306-279(294)295)265(433)339-182(114-142(5)6)248(416)338-180(93-96-218(389)390)276(444)368-111-52-74-206(368)277(445)367-110-51-73-205(367)268(436)349-189(122-162-81-89-166(376)90-82-162)259(427)362-224(152(17)370)269(437)317-133-216(386)365-108-49-71-203(365)266 |
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分类
- {SNA} AN-
- {SNA} Enzyme Inhibitors,
- {SNA} A to C, AN-AZ, Analytical and Industrial Enzymes, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, Carboxypeptidase Y,
- {SA} AN-AZ, Analytical and Industrial Enzymes, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates,
- {SNA} Biochemicals and Reagents,
- {SNA} A to C,
- {SNA} Analytical and Industrial Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Type, Proteins, Recombinant Alternatives to Animal Source Proteins, Recombinant Alternatives to Bovine Source Proteins, 生化试剂, 酶、抑制剂和底物
相关文献及参考
- Hansen, A., et al., Development Of A Drug Screening Platform Based On Engineered Heart Tissue. Circ. Res. 107 , 35-44, (2010) 摘要
- Zallocchi, M., et al., Biochemical Characterization Of Native Usher Protein Complexes From A Vesicular Subfraction Of Tracheal Epithelial Cells. Biochemistry 49 , 1236-47, (2010) 摘要
- Shin, Y.P., et al., Antimicrobial Activity Of A Halocidin-derived Peptide Resistant To Attacks By Proteases. Antimicrob. Agents Chemother. 54 , 2855-66, (2010) 摘要
- Banaszynski, L.A., et al., Analysis Of Histones And Chromatin In Xenopus Laevis Egg And Oocyte Extracts. Methods 51 , 3-10, (2010) 摘要
- Slobodin, B., and Gerst, J.E., RaPID: An Aptamer-based MRNA Affinity Purification Technique For The Identification Of RNA And Protein Factors Present In Ribonucleoprotein Complexes. Methods Mol. Biol. 714 , 387-406, (2011) 摘要
- Trautschold, I., et al. Biochem. Pharmacol. 16 , 59, (1967)
- Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182 , 83-89, (1990)
- Dignam, J.D., Preparation of extracts from higher eukaryotes. Meth. Enzymol. 182 , 194-203, (1990) 摘要
- Gebhard, W., Review: Biochemistry of aprotinin and aprotinin-like inhibitors. Res. Monogr. Cell Tissue Physiol. 12 , 375, (1986)
- McEvoy, M.D., et al., Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action Anesth. Analg. 105 , 949-962, (2007)
- Aprotinin in perspective, Aprotinin in perspective Ann. Thorac. Surg. 55(4) , 1033-1041, (1993)
- , Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach , (1989), 247
- Merck 14 ,757
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
- P301+P312
- P302+P352
- P304+P341
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P333+P313
- P342+P311
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
