(2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol (2E,6E,10E)-3,7,11,15-四甲基十六烷-2,6,10,14-四烯-1-醇
CAS 24034-73-9 MFCD00129083
化学结构图
SMILES: CC(C)CCCC(C)CCCC(C)CCC/C(/C)=C/CO
化学属性
| Mol. Formula | C20H34O |
|---|---|
| Mol. Weight | 290 |
别名和识别编码
| Chemical Name | (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol |
|---|---|
| CAS Number | 24034-73-9 |
| Synonym | (2E,6E,10E)-3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol (E,E,E)- 3,7,11,15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol (E,E,E)-Geranylgeraniol All-trans-Geranylgeraniol all trans-3,7,11-15-Tetramethyl-2,6,10,14-hexadecatetraen-1-ol trans,trans,trans-G |
| MDL Number | MFCD00129083 |
| PubChem Substance ID | 24895120 |
| Beilstein Registry Number | 1913779 |
| Chemical Name Translation | (2E,6E,10E)-3,7,11,15-四甲基十六烷-2,6,10,14-四烯-1-醇 |
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分类
- {SNA} Biochemicals and Reagents, Cancer Metabolism, Cancer Research, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Isoprenoids, Key Mevalonate Metabolites Implicated In Cancer,
- {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Type, Isoprenoids, Prenols, Substrate Analogs, Terpenoids, 代谢组学, 代谢通路, 参与癌症的关键甲羟戊酸代谢物, 生化试剂, 癌症中的甲羟戊酸途径, 癌症代谢, 癌症研究, 细胞生物学, 脂类, 萜类代谢, 酶、抑制剂和底物
- Biochemicals and Reagents, Cancer Metabolism,
产品应用
- Geranylgeraniol, a precursor to Geranylgeranylpyrophosphate (G367600), is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-adsorption, inhibition of osteocl
相关文献及参考
- Aiuchi, T., et al.: J. Biochem., 124, 300 (1998),
- Fisher, J.E., et al.: Proc. Natl. Acad. Sci. U.S.A. 96, 133 (1999),
- Montero, M.T., et al.: J. Immunol., 173, 4936 (2004),
- 1. Vik, A., et al., Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro Planta Med. 73 , 1410-1412, (2007)
- Kotti, T.J., et al., Brain cholesterol turnover required for geranylgeraniol production and learning in mice Proc. Natl. Acad. Sci. U. S. A. 103 , 3869-74, (2006) 摘要
- Kotti, T., et al., Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation Proc. Natl. Acad. Sci. U. S. A. 105 , 11394-9, (2008) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
