2H-​Indol-​2-​one, 3-​[[4-​(dimethylamino)​phenyl]​methylene]​-​1,​3-​dihydro- 3-[[4-(二甲基氨基)苯基]亚甲基]-1,3-二氢-2H-吲哚-2-酮

CAS 5812-07-7 MFCD00118147

化学结构图

5812-07-7
SMILES: CN(C)c1ccc(C=C2C(=O)Nc3ccccc32)cc1

化学属性

Mol. FormulaC17H16N2O
Mol. Weight264

别名和识别编码

Chemical Name2H-​Indol-​2-​one, 3-​[[4-​(dimethylamino)​phenyl]​methylene]​-​1,​3-​dihydro-
Synonym 3-(4-Dimethylaminobenzylidenyl)-2-indolinone 3-(4-Dimethylaminobenzylidenyl)-2-indolinone 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture 3-(4-dimethylaminobenzylidene)-1,3-dihydroindol-2-one 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture SU 4312 SU-4312 SU4312
MDL NumberMFCD00118147
PubChem Substance ID6450842
CAS Number5812-07-7
Chemical Name Translation3-[[4-(二甲基氨基)苯基]亚甲基]-1,3-二氢-2H-吲哚-2-酮
InChIKeyUAKWLVYMKBWHMX-PTNGSMBKSA-N
InChIInChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11-
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分类

  • {SNA} Bioactive Small Molecule Alphabetical Index,
  • {SNA} Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Kinase/Phosphatase Biology, P to Q, Protein Kinase Inhibitors, Protein kinase, tyrosine, EGF receptor, Protein kinase, tyrosine, PDGFR, Protein kinase, tyrosine, VEGFR, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, S, Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR), 细胞生物学
  • {SNA} Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Kinase/Phosphatase Biology,
  • {SNA} Bioactive Small

相关文献及参考

  • Kendall, R.L., et al., Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J. Biol. Chem. 274 , 6453-5460 , (1999) 摘要

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
WGK Germany3
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Protein kinase, tyrosine, PDGFR - P to Q
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Receptor Tyrosine Kinase Inhibitors - Receptor Tyrosine Kinase Biology
  7. Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR) - Receptor Tyrosine Kinase Inhibitors

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