Meprednisone 甲基泼尼松

CAS 1247-42-3 MFCD00083662

化学结构图

1247-42-3
SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO

化学属性

Mol. FormulaC22H28O5
Mol. Weight372.50
SolubilitySoluble in Chloroform and Methanol
Melting Point204-206°C

别名和识别编码

Chemical NameMeprednisone
CAS Number1247-42-3
Synonym Betalone 16-beta-Metilprednisone 16-beta-Methylprednisone Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-16-methyl-, (16-beta)- Betanisona Deltacortene beta Bitanisone (16?)- 泼尼松; 16-甲基泼尼松 17-Hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione Lepicortin-beta Meprednisone Betapar Betapred Deltisona B
MDL NumberMFCD00083662
EC Number214-996-1
Chemical Name Translation甲基泼尼松
Wiswesser Line NotationL E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ G1
LabNetwork Molecule IDLN01287683
PubChem Substance ID5284587
InChIInChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1
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分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids,

产品应用

  • Corticosteroid.

相关文献及参考

  • Rosenfeld, S., et al.: Blood, 85, 3058
  • [1]. Scheuer, E. and E. Warshaw, Allergy to corticosteroids: update and review of epidemiology, clinical characteristics, and structural cross-reactivity. Am J Contact Dermat, 2003. 14(4): p. 179-87.

安全信息

Storage condition 储存温度-20°C 储存温度 2-8°C
RTECSTU4154090 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 14 mg/kg
SEX/DURATION            : female 16-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 30,1098,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6250 ug/kg
SEX/DURATION            : female 15-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   PEREBL Pediatric Research.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1967-  Volume(issue)/page/year: 11,1042,1977

其他信息

  • Meprednisone是一种糖皮质激素，也是Prednisone的甲基化衍生物。

系列性分类

  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)

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