Methyl [5-(Propylthio)Benzimidazol-2-yl]Carbamate 丙硫咪唑

CAS 54965-21-8 MFCD00083232

化学结构图

54965-21-8
SMILES: CCCSC1=CC2N=C(NC(=O)OC)NC=2C=C1

化学属性

Mol. FormulaC12H15N3O2S
Mol. Weight265
Melting Point208-210°
TSCANo
Density1.3
Solubility在丙酮或氯仿中微溶,不溶于水,微溶于热稀盐酸,可溶于甲醇、乙醇、乙酸等。
Boiling Point79-80

别名和识别编码

Chemical NameMethyl [5-(Propylthio)Benzimidazol-2-yl]Carbamate
CAS Number54965-21-8
Synonym ((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle (5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester 5-(丙硫基)-2-苯并咪唑氨基甲酸甲酯 Albendazole Methyl [5-(Propylthio)benzimidazol-2-yl]carbamate; [5-(Propylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester
MDL NumberMFCD00083232
EC Number259-414-7
Merck Number210
PubChem Substance ID87558956
Chemical Name Translation丙硫咪唑
Reaxys-RN752696
Beilstein Registry Number752696
Wiswesser Line NotationT56 BM DNJ CMVO1 GS3
LabNetwork Molecule IDLN00225752
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分类

  • Sulfur & Selenium Compounds
  • {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
  • Heterocycles
  • {SNA} A, AA to AL, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antiparasitic / Antiprotozoal / Anthelminthic, Benzimidazoles, Chemical Structure Class,
  • Pharmaceuticals
  • {SNA} Additional Standards, Analytical Standards, Chromatography, Pharmaceutical Secondary Standards, P
  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards A - B, 分析/色谱

产品应用

  • 该品为高效、广谱驱虫新药,对肝片吸虫,绦虫、肺和胃肠道线虫均有显著药效。为苯并咪唑类药物中租用最强的一种,是目前防治畜禽寄生虫病的首选药物。该品对牛、羊肝片吸虫成虫和幼虫,大片吸虫均有效,减虫率可达90-100%,今年来,发现该品对牛囊尾蚴亦有很强的作用,治疗后囊尾蚴减少,病灶消失。此外,改频还可用于预防寄生虫的感染,因此对于促进绵羊的生长增加羊毛产量,均可收到较好的效果。

相关文献及参考

  • Zhao, Y., et al.: Org. Biomol. Chem., 6, 4509 (2008),
  • Merck: 14,210
  • Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),

安全信息

Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
  • R33 Danger of cumulative effects 有累积作用的危险
WGK Germany2
GHS Symbol
Hazard statements
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H303 May be harmfully swallowed 吞食可能有害
RTECSFD1100000
Signal word Warning
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xn
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P350
  • P304+P340+P312
  • P308+P313
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APFRAD Annales Pharmaceutiques Francaises.  (SPPIF, B.P.22, F-41353 Vineuil,
   France)  V.1-    1943-  Volume(issue)/page/year: 40,55,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALSMAS Acta Leidensia.  (Institute of Tropical Medicine Rotterman-Leiden,
   Wassenaarseweg 62, 2333 AL Leiden, Netherlands)  (Suspended 1942-45); V.1-
   1925/26-  Volume(issue)/page/year: 57,201,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,99,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 265 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,99,1995

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,185,1995

{hazard_com

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OB

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 85 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ARCVBP Annales Recherches Veterinaires.  (Institut National de la Recherche
   Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles,
   France)  V.1-    1970-  Volume(issue)/page/year: 12,159,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 20 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   AMSHAR Acta Morphologica Academiae Scientiarum Hungaricae.  (Budapest,
   Hungary)  V.1-30, 1951-82.  Volume(issue)/page/year: 28,226,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   9,265,1995

TYPE OF TEST            : TDLo - L

其他信息

  • 微溶于有机溶剂,不溶于水。无臭。

系列性分类


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