CAS 60719-84-8 MFCD00083228-5-Amino-[3,4'-bipyridin]-6(1H)-one 5-氨基-[3,4-联吡啶]-6(1H)-酮 TAO{mole}

5-Amino-[3,4'-bipyridin]-6(1H)-one 5-氨基-[3,4-联吡啶]-6(1H)-酮

CAS 60719-84-8 MFCD00083228

化学结构图

SMILES: NC1=CC(=CNC1=O)C1C=CN=CC=1

化学属性

Mol. Formula	C10H9N3O
Mol. Weight	187.22
TSCA	No
Melting Point	294-297° dec
Density	1.277

别名和识别编码

Chemical Name	5-Amino-[3,4'-bipyridin]-6(1H)-one
CAS Number	60719-84-8
Synonym	5-Amino-1,6-dihydro-6-oxo-[3,4'-bipyridine] Win 40680 AWD 08-250 氨力农 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone Cartonic Amrinone 5-Amino-(3,4'-bipyridin)-6(1H)-one 3-Amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridone Inamrinone WIN 40680 Winc Vesistol 5-Amino(3,4'-bipyridin)-6-(1H)-one 5-氨基-[3 4'双吡啶]-6(1H)-酮 5-Amino-[3,4'-bipyridin]-6(1H)-one Cordemcura
MDL Number	MFCD00083228
PubChem Substance ID	24890741
EC Number	262-390-0
Merck Number	14,592
Chemical Name Translation	5-氨基-[3,4-联吡啶]-6(1H)-酮
Beilstein Registry Number	0744819

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

非苷类强心剂。应于各种类型的充血性心力衰竭，尤其对洋地黄、利尿剂及扩血管药疗效不佳的顽固性心衰。

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P301+P310

Hazard statements

H301 Toxic if swallowed 吞食有毒

RTECSDW2500000

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Packing GroupIII

UN Number UN2811

Risk Statements

R25 Toxic if swallowed 吞咽有毒

Hazard Codes T

Storage condition 储存温度 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 212 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 24,1111,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 288 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPHSDY Trends in Pharmacological Sciences.  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1979-
   Volume(issue)/page/year: 1,143,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 24,1111,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 3 mg/kg/15M-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
REFERENCE :
   CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).  (C.V. Mosby Co.,
   11830 Westline Industria

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   41,214,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 138 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 24,1883,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted f

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE

其他信息

无色，无味，遇光色渐变深。