Aconitine (剧毒品,不能销售)乌碱
CAS 302-27-2 MFCD00082375
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分类
- {SNA} A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels
- A-AM, Amiloride and Derivatives, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels
- {SNA} A-AM, Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Ion Channels, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gat
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相关文献及参考
- Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010),
- Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),
- Ameri, A., The effects of Aconitum alkaloids on the central nervous system. Prog. Neurobiol. 56 , 211-235, (1998) 摘要
- Onur, R., et al., Effects of aconitine on neurotransmitter release in the rat neuromuscular junction. Neuropharmacology 34 , 1139-1145, (1995) 摘要
- Seitz, U., and Ameri, A, Different effects on [ 3 H]noradrenaline uptake of the Aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetyllappaconitine in rat hippocampus. Biochem. Pharmacol. 55 , 883-888, (1998) 摘要
- Sawanobori, T., Effects of arrhythmic agents and Mg 2+ on aconitine-induced arrhythmias. Jpn. Heart J. 5 , 709, (1996)
- Ameri, A. and Simmet, T, Antagonism of the aconitine-induced inexcitability by the structurally related aconitum alkaloids, lappaconitine and ajacine. Brain Res. 842 , 332-341, (1999) 摘要
- Zhang, H.F. and Shi, Y.P., Preparation of Fe 3 O 4 nanoparticle enclosure hydroxylated multi-walled carbon nanotubes for the determination of aconitines in human serum samples Anal. Chim. Acta 724 , 54-60, (2012)
- Li, N., et al., Intestinal Transport of Pure Diester-type Alkaloids from an Aconite Extract across the Caco-2 Cell Monolayer Model Planta Med. 78(7) , 692-7, (2012)
- Liu, Y., et al., Study on the aconitine-type alkaloids of Radix Aconiti Lateralis and its processed products using HPLC-ESI-MS(n). Drug Test. Anal. , doi: 10.1002/dta.416., (2012)
- Merck 14 ,118
- Beil. 21 ,V,6,310
安全信息
GHS Symbol
- H330 Fatal if inhaled 吸入致命
- H300 Fatal if swallowed 吞食致命
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S24 Avoid contact with skin 避免皮肤接触;
- R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 350 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1291,1935
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 ug/kg TOXIC EFFECTS : Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 26,221,1928
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(1),159,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 2,225,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guin