CAS 64-73-3 MFCD00082371-(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride (4S,4aS,5aS,6S,12aS)-7-氯-4-(二甲氨基)-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺盐酸盐 TAO{mole}

(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride (4S,4aS,5aS,6S,12aS)-7-氯-4-(二甲氨基)-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺盐酸盐

CAS 64-73-3 MFCD00082371

化学结构图

SMILES: CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)ccc(Cl)c4[C@@H](O)[C@H]3C[C@@H]12.Cl

化学属性

Mol. Formula	C21H22Cl2N2O8
Mol. Weight	501
TSCA	No
Melting Point	245
Solubility	Soluble in water (20 mg/ml), DMSO, and methanol.

别名和识别编码

Chemical Name	(4S,4As,5As,6S,12As)-7-Chloro-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-1,11-Dioxo-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide Hydrochloride
CAS Number	64-73-3
Synonym	######## 7-Chloro-6-demethyltetracycline hydrochloride 7-Chloro-6-demethyltetracycline hydrochloride Demethylchlorotetracycline hydrochloride 7-Chloro-6-demethyltetracycline hydrochloride 7-氯-4-二甲氨基-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐 Demeclocycline hydrochloride Demethylchlorotetracycline hydrochloride Demethylchlortetracycline hydrochloride Detravis Ledermycin hydrochloride 地美环素盐酸盐盐酸地美环素; 盐酸去甲金霉素; 7-氯-4-二甲氨基-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐
MDL Number	MFCD00082371
PubChem Substance ID	54686764
Beilstein Registry Number	3849198
EC Number	200-592-2
Merck Number	14,2886
Chemical Name Translation	(4S,4aS,5aS,6S,12aS)-7-氯-4-(二甲氨基)-3,6,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺盐酸盐
Wiswesser Line Notation	L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ OGRQ &GH
LabNetwork Molecule ID	LN00202430
InChI	InChI=1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-27,30,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An antibiotic related to tetracycline and produced by streptomyces aureofaciens.

安全信息

WGK Germany2

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏

RTECSQI7700000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xi

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 储存温度：-20°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,704,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AISMAE Archivio Italiano di Scienze Mediche Tropical e di Parassitologia.
   Italian Archives of the Science of Tropical Medicine and Parasitology.
   (Rome, Italy)  V.1-54, 1920-73.  Suspended.  Volume(issue)/page/year:
   43,143,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 69 mg/kg

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2372 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,704,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 29,553,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 48 ug/kg
SEX/DURATION            : female 28 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 34,423,1964