Forskolin, 98% (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(乙酰氧基)-3-乙烯基十二烷基-6,10,10b-三羟基-3,4a,7,7,10a-五甲基-1H- 萘并[2,1-b]吡喃-1-酮
CAS 66575-29-9 MFCD00082317
化学结构图
SMILES: CC1(C)CC[C@H](O)[C@@]2(C)[C@H]1[C@H](O)[C@H](OC(C)=O)[C@@]1(C)O[C@](C)(CC(=O)[C@@]12O)C=C
化学属性
| Mol. Formula | C22H34O7 |
|---|---|
| Mol. Weight | 411 |
| TSCA | No |
| Solubility | Soluble in DMSO or ethanol. |
| Melting Point | 228 |
别名和识别编码
| Chemical Name | Forskolin, 98% |
|---|---|
| CAS Number | 66575-29-9 |
| Synonym | (-)-Forskolin (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one Coleonol Colforsin Coleonol Colforsin ForsLean Forskolin HL 362 L 7 |
| PubChem Substance ID | 253661985 |
| EC Number | 266-410-9 |
| Beilstein Registry Number | 1692716 |
| MDL Number | MFCD00082317 |
| Merck Number | 2476 |
| Chemical Name Translation | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(乙酰氧基)-3-乙烯基十二烷基-6,10,10b-三羟基-3,4a,7,7,10a-五甲基-1H- 萘并[2,1-b]吡喃-1-酮 |
| Reaxys-RN | 4300863 |
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分类
- Adenylyl Cyclase Activators, Antitumor Agents, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzyme Activators, F, G Proteins and Cyclic Nucleotides, Isoprenoids, Lipids,
- {SNA} Adenylyl Cyclase Activators, Antitumor Agents, Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, Enzyme Activators,
- {SNA} Biochemicals, Isoprenoids, Prenols, 分子生物学, 分子生物学试剂, 生化试剂, 脂类
- {SNA} Alphabetical Index of Phytochemical Standards,
- {SNA} Adenylyl Cyclase Activat
产品应用
- Diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties.
相关文献及参考
- [2]. Matsumiya W, et al. Forskolin modifies retinal vascular development in Mrp4-knockout mice. Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8029-35.
- [3]. Mayati A, et al. Functional polarization of human hepatoma HepaRG cells in response to forskolin. Sci Rep. 2018 Oct 31;8(1):16115.
- [4]. Awad JA, et al. Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide. J Biol Chem. 1983 Mar 10;258(5):2960-5.
- [5]. Seamon KB, et al. Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J Med Chem. 1983 Mar;26(3):436-9.
- [6]. Ríos-Silva M, et al. Effect of chronic administration of forskolin on glycemia and oxidative stress in rats with and without experimental diabetes. Int J Med Sci. 2014 Mar 11;11(5):448-52.
- [7]. Rodriguez G, et al. Forskolin-inducible cAMP pathway negatively regulates T-c
安全信息
GHS Symbol
- H303 May be harmfully swallowed 吞食可能有害
- H312 Harmful in contact with skin 皮肤接触有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R21 Harmful in contact with skin 与皮肤接触有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 68 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 3,1,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MRREDD Medicinal Research Reviews. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1981- Volume(issue)/page/year: 3,201,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MRREDD Medicinal Research Reviews. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1981- Volume(issue)/page/year: 3,201,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 92 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 31,1872,1988
