Uricase [10 units/mg] 尿酸酶
CAS 9002-12-4 MFCD00082126
化学结构图
SMILES: N.O=c1ccn(C2OC(COP(=O)(O)OC3C(CO)OC(n4ccc(=O)[nH]c4=O)C3O)C(O)C2O)c(=O)[nH]1
化学属性
| Density | 1.422 |
|---|---|
| Mol. Weight | |
| Mol. Formula | N/A |
别名和识别编码
| MDL Number | MFCD00082126 |
|---|---|
| PubChem Substance ID | 14228836 |
| CAS Number | 9002-12-4 |
| EC Number | 232-655-5 |
| Synonym | Urate oxidase Urate oxidase, Urate:O2 oxidoreductase Urate oxidase; Urate:O2-oxidoreductase; Uratoxidase; Uric acid oxidase; Uricase; Uricozyme Urate: oxygen oxoreductase |
| Beilstein Registry Number | 2384789 |
| Chemical Name | Uricase [10 units/mg] |
| Chemical Name Translation | 尿酸酶 |
| InChI | InChI=1S/C18H23N4O14P.H3N/c23-5-7-14(13(28)16(34-7)22-4-2-10(25)20-18(22)30)36-37(31,32)33-6-8-11(26)12(27)15(35-8)21-3-1-9(24)19-17(21)29;/h1-4,7-8,11-16,23,26-28H,5-6H2,(H,31,32)(H,19,24,29)(H,20,25,30);1H3 |
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资金保障
专业采购外包团队在线服务
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分类
- {SNA} 1.7.x.x Other nitrogenous donors, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, General Metabolic Enzymes, General Metabolic Enzymes I-Z,
- 1.7.x.x Other nitrogenous donors, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Enzyme Class Index,
- {SNA} 1.7.x.x Other nitrogenous donors, 1.x.x.x Oxidoreductases, Biochemicals and Reagents, Enzyme Class Index, Enzymes, Inhibitors, and Subs
- {SNA} 1.7.x.x Other nitrogenous donors,
- {SNA} 1.7.x.x Other nitrogenous donors, 1.x.x.x Oxidoreductases, Enzyme Class Index, General Metabolic Enzymes, General Metabolic Enzymes I-Z, 代谢组学, 生化试剂, 细胞生物学,
产品应用
- Oxidizes uric acid
相关文献及参考
- Merck 14 ,9876
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R60 May impair fertility 可能降低生殖能力
- R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
- R42 May cause sensitisation by inhalation 吸入会产生过敏反应
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,1914,1972
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 6,1914,1972
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
其他信息
- Uricase from Candida yeast has a molecular weight of ~120,000 daltons and an optimum pH of 8.5. The enzyme is stable at pH 8.5-9.5 and at temperatures below 35°C. The pI is 5.6. It is inhibited by various purine analogs of urate, and by copper chelating agents. The enzyme is highly specific for uric acid.
