CAS 37189-34-7 MFCD00081423-Bromelain 菠萝酶 TAO{mole}

Bromelain 菠萝酶

CAS 37189-34-7 MFCD00081423

化学结构图

SMILES:

化学属性

Solubility	可溶
Appearance	powder

别名和识别编码

MDL Number	MFCD00081423
CAS Number	37189-34-7
EC Number	253-387-5
Synonym	3.4.22.32 Ananase BROMELAIN BROMELAIN PINEAPPLE BROMELIN Bromelain, juice BromelainExPineappleStemJuice Bromelains Bromelin CATHEPSIN B (LIVER) CATHEPSIN B, HUMAN CATHEPSIN B, HUMAN LIVER CATHEPSIN B1 E.C. 3.4.4.24 EC 3.4.22.1 EC 3.4.22.32 EC 3.4.22.4 EC 3.4.22.5 EC: 3.4.22.4 Plant protease concentrate STEM BROMELAIN ananase bromelains e.c.3.4.4.24 plantproteaseconcentrate 菠罗蛋白酶菠萝蛋白酶菠萝蛋白酶; 菠萝酶菠萝酶
Chemical Name	25GR Bromelain from pineapple stem >=3 units/mg protein
Chemical Name Translation	菠萝酶

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分类

3.4.x.x Peptidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Bromelain, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Functional Foods, Nutrition Research, Protease, Proteases, Proteases & Protein Sequencing, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Selective Proteolytic Enzymes
{SNA} 3
{Chemicalbook} 食品添加剂: 酶和微生物制剂: 酶
{SA} 3.4.x.x Peptidases, 3.x.x.x Hydrolases, Biochemicals and Reagents, Bromelain, Enzyme Class Index, Enzymes, Inhibitors, and Substrates, Proteolytic Enzymes, Proteolytic Enzymes and Substrates, Sel

安全信息

GHS Symbol

WGK Germany1

Precautionary statements

P342+P311
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Signal word Danger

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes Xn B,Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S24 Avoid contact with skin 避免皮肤接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R42 May cause sensitisation by inhalation 吸入会产生过敏反应

Storage condition -20°C

RTECSEF8575000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85200 ug/kg
TOXIC EFFECTS :
   Behavioral - irritability
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 145,166,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   18

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 145,166,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 145,166,1963

其他信息

生产方法:由菠萝(Ananas comoslgs和A.bracteatus)果实及茎(主要利用其外皮)经压榨提取、盐析(或丙酮、乙醇沉淀)再分离、干燥而得。
用途:作为药物，适用于各种急性、慢性炎症及水肿；外科创伤或手术后伤口愈合，骨折或脱臼引起的炎症，水肿、血肿、哮喘性支气管炎、肺炎、肺脓肿、骨髓炎、关节炎、蜂窝组织炎、肾盂肾炎、血栓静脉管炎及其他发炎、肿胀疾病。作为食品加工助剂，主要用于啤酒抗寒、肉类软化、各类预煮准备、水解蛋白质的生产。
参考质量标准:见160酶制剂。
毒害物质数据:9001-00-7(Hazardous Substances Data)
菠萝蛋白酶价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 402835000 菠萝蛋白酶 Bromelain , pure 500 GR 3672元 2010/06/21 402830250 菠萝蛋白酶 Bromelain , pure 25 GR 418元 2010/06/21 402831000 菠萝蛋白酶 Bromelain , pure 100 GR 977元
使用限量:用于分割肉的处理液或注射液中的含量不超过3%(以原料计；USDA，§318.7，§318.147；2000)。
color:yellow-brown
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg）菠萝蛋白酶食品酶制剂按生产需要适量使用（有特别规定的除外）
F:10-21
EPA化学物质信息:Bromelain, juice(9001-00-7)
海关编码:35079090
毒性:ADI不作限制性规定(FAO/WHO，2001)。 GRAS(美国BATF，27CFR， §240.1051，2000)。