5’-Adenosine Triphosphate (ATP) Disodium Salt Purity Reference Material 5’-三磷酸腺苷（ATP）二钠盐纯度标准物质

CAS 987-65-5 MFCD00080339

化学结构图

987-65-5
SMILES: Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)(O)O)[C@@H](O)[C@H]1O.[Na+].[Na+]

化学属性

Mol. FormulaC10H14N5Na2O13P3
Mol. Weight551.14
SolubilitySoluble in water (110 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), DMF (sparingly), and PBS pH 7.2 (~10 mg/ml)., Soluble in water (110 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), DMF (sparingly)
Appearance crystalline
Density2.63
Melting Point175°C

别名和识别编码

Chemical Name5’-Adenosine Triphosphate (ATP) Disodium Salt Purity Reference Material
Synonym ATP (disodium salt) {LY} ATP (disodium salt) {} {LY} ATP (disodium salt) {} {} {LY} ATP (disodium salt) {} {} {} {LY} ATP (disodium salt) {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} ATP (disodium salt) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} A
MDL NumberMFCD00080339
PubChem Substance ID87561840
CAS Number987-65-5
Reaxys-RN3585462
Merck Number155
EC Number213-579-1
Beilstein Registry Number6264880
Chemical Name Translation5’-三磷酸腺苷（ATP）二钠盐纯度标准物质
Wiswesser Line NotationT56 BN DN FN HNJ IZ D- BT5OTJ CQ DQ E1OPQO&OPQO&OPQQO&-NA- 2
LabNetwork Molecule IDLN00188865
Canonical SMILESO[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(OP(OP(O)([O-])=O)([O-])=O)(O)=O.[2Na+]
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分类

  • Biochemicals and Reagents, Molecular Biology, Molecular Biology Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides, Ribonucleotides
  • {SNA} Nucleotides, Ribonucleotides, 分子生物学, 分子生物学试剂, 核苷，核苷酸和寡核苷酸, 生化试剂
  • {SNA} Biochemicals and Reagents, Molecular Biology, Molecular Biology Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides, Ribonucleotides
  • {SNA} Biochemicals and Reagents, Nucleosides, Nucleotides, Oligonucleotides, Nucleotides, Ribonucleotides, 分子生物学, 分子生物学试剂

产品应用

  • P2 嘌呤能激动剂；增加Ca2+-激活的K+ 通道活性；依赖ATP的酶底物。

相关文献及参考

  • [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.
  • [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.
  • [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.
  • Merck: 14,155
  • [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.
  • [1]. Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.
  • [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammati

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RTECSAU7417000
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {}
GHS Symbol
Safety Statements 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,20,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,20,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 266 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,20,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,20,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo J

Precautionary statements

其他信息

  • TCI Shanghai:腺苷-5'-三磷酸二钠盐水合物 Adenosine 5'-Triphosphate Disodium Salt Hydrate,>;98.0%(LC)(T)(987-65-5)
  • 毒性分级:中毒
  • 类别:有毒物品
  • 可燃性危险特性:可燃; 燃烧释放有毒氮氧化物, 氧化钠和磷氧化物烟雾
  • 图谱信息:腺苷-5'-三磷酸二钠盐(987-65-5)红外图谱(IR2) 腺苷-5'-三磷酸二钠盐(987-65-5)红外图谱(IR1)
  • MSDS 信息:Adenosine 5'-triphosphate disodium salt(987-65-5).msds
  • MOL 文件:987-65-5.mol
  • 急性毒性:口服-大鼠 LD50: >;2000毫克/公斤;口服-小鼠 LD50: 2000毫克/公斤
  • 储运特性:库房通风低温干燥; 与食品原料分开存放
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • F:10-21
  • 腺苷-5'-三磷酸二钠盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0157 腺苷-5'-三磷酸二钠盐水合物 Adenosine 5'-Triphosphate Disodium Salt Hydrate 25G 2160元 2011/04/16 A0157 腺苷-5'-三磷酸二钠盐水合物 Adenosine 5'-Triphosphate Disodium Salt Hydrate 1G 275元
  • Adenosine 5'-Triphosphate, disodium salt is a p2 purinergic (P2X and P2Y) agonist that increases Ca2+-activated K+ channel activity. It has been found to induce a release of prostoglandin D2 and histamine from rat peritoneal mast cells in a dose-dependent manner.
  • Sigma Aldrich:987-65-5(sigmaaldrich)
  • 用途一:P2 嘌呤能激动剂；增加Ca2+-激活的K+ 通道的活性；ATP依赖酶系统的底物。
  • 易溶于水，不溶于乙醇，本品水溶液显钠盐火焰反应。
  • 腺苷-5'-三磷酸二钠盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0157 腺苷-5'-三磷酸二钠盐水合物 Adenosine 5'-Triphosphate Disodium Salt Hydrate 25G 2620元 2014/06/02 A0157 腺苷-5'-三磷酸二钠盐水合物 Adenosine 5'-Triphosphate Disodium Salt Hydrate 1G 334元

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleosides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotide Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Molecular Biology 分子生物学
  3. Molecular Biology Reagents - Molecular Biology
  4. Nucleotides - Molecular Biology Reagents
  5. Ribonucleotides - Nucleotides
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. DNA / RNA Synthesis
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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