CAS 101-26-8 MFCD00079283-Pyridostigmine bromide 溴化吡斯的明 TAO{mole}

Pyridostigmine bromide 溴化吡斯的明

CAS 101-26-8 MFCD00079283

化学结构图

SMILES: CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-]

化学属性

Mol. Formula	C9H13BrN2O2
Mol. Weight	261.12
Appearance	溴吡斯的明(101-26-8)为淡黄色至无色液体，溶于乙醇及水。
Melting Point	153.0 to 157.0 deg-C

别名和识别编码

Chemical Name	Pyridostigmine bromide
MDL Number	MFCD00079283
CAS Number	101-26-8
Synonym	吡斯的明 3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide PYBR 吡啶斯的明 Pyridinium, 3-(((dimethylamino)carbonyl)oxy)-1-methyl-, bromide 3-Hydroxy-1-methylpyridinium bromide dimethylcarbamate (ester) 3-DIMETHYLAMINOCARBONYLOXY-N-METHYL-PYRIDINIUM BROMIDE 溴化 1-甲基-3-羟基吡啶二甲氨基甲酸酯 PYRIDOSTIGMINE BROMIDE 3-(dimethylcarbamyloxy)-1-methylpyridiniumbromide 3-(((dimethylamino)carbonyl)oxy)-1-methyl-pyridiniubromide 溴化3-二甲氨基甲酰氧基-1-甲基吡啶 Mestinon Ro 1-5130 溴化吡啶斯的明 dimethylcarbamicacidesterof3-hydroxy-1-methylpyridiniumbromide Pyridostigmine bromide; 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide kalymin 金丝桃素,金丝桃蒽酮 Pyridostigmine bromide 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate(ester) pyridinium,3-hydroxy-1-methyl-,bromide,dimethylcarbamate(ester) Regonal mestinonebromide pyridinium,3-hydroxyl-1-methyl-,bromide,dimethylcarbamate 溴化 1-甲基-3-羟基吡啶鎓二甲氨基甲酸酯溴吡斯的明 kalimin Kalimin 3-(DIMETHYLAMINOCARBONYLOXY)-1-METHYLPYRIDINIUM BROMIDE regonal 1-methyl-3-hydroxypyridiniumbromidedimethylcarbamate Mestinone bromide mestinon 3-二甲胺基酰氧基吡啶 3-(DIMETHYLCARBAMOYLOXY)-1-METHYLPYRIDINIUM BROMIDE Dimethylcarbamic acid ester of 3-hydroxy-1-methylpyridinium bromide mestinonbromide 3-hydroxy-1-methylpyridiniumbromidedimethylcarbamate ro1-5130
PubChem Substance ID	7550
EC Number	202-929-9
Reaxys-RN	3764573
Merck Number	7977
Chemical Name Translation	溴化吡斯的明
Wiswesser Line Notation	T6KJ A1 COVN1&1 &E
LabNetwork Molecule ID	LN00226106
InChI	InChI=1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1

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安全信息

RTECSUU5270000

WGK Germany3

GHS Symbol

Precautionary statements

P301+P310+P330
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P302+P350
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Signal word Danger

Hazard statements

H330 Fatal if inhaled 吸入致命
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H310 Fatal in contact with skin 皮肤接触致命
H300 Fatal if swallowed 吞食致命

Hazard Codes T+

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

UN Number UN 2811 6.1/PG 2 2811

Packing GroupII

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MECHAN Medicinal Chemistry, A Series of Reviews.  (New York, NY)  V.1-6,
   1951-63.  Discontinued.  Volume(issue)/page/year: 3,329,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2699 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   4,S195,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - fasciculations
REFERENCE :
   IJMDAI Israel Journal of Medical Sciences.  (POB 1435, Jerusalem 91013,
   Israel)  V.1-    1965-  Volume(issue)/page/year: 27,659,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,145,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 630 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 280 mg/kg
SEX/DURATION            : female 15-21 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 69,291,1991

其他信息

用途一:抗胆碱酯酶药，用于重症肌无力、手术后功能性肠胀气及尿潴留
MSDS 信息:Mestinon(101-26-8).msds
MOL 文件:101-26-8.mol
TCI Shanghai:溴化吡斯的明 Pyridostigmine Bromide,>;98.0%(T)(101-26-8)
溴吡斯的明价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 P1339 溴吡斯的明 Pyridostigmine Bromide 5G 1560元 2014/06/02 P1339 溴吡斯的明 Pyridostigmine Bromide 25G 4560元
Sigma Aldrich:101-26-8(sigmaaldrich)