Pentamidine isethionate 喷他脒羟乙磺酸盐
CAS 140-64-7 MFCD00079213
化学结构图
SMILES: N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1.O=S(=O)(O)CCO.O=S(=O)(O)CCO
化学属性
| Mol. Formula | CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H |
|---|---|
| Mol. Weight | 593 |
| Melting Point | 188-194 °C(lit.) |
| Appearance | powder |
别名和识别编码
| Chemical Name | Pentamidine isethionate |
|---|---|
| Synonym | 1,5-BIS(P-AMIDINOPHENOXY)PENTANE BIS(2-HYD 1,5-BIS[P-AMIDINOPHENOXY]PENTANE BIS[2-HYDROXYETHANESULFONATE SALT] ISETHIONATE SALT 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt) 4,4'-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate) 2512 R.P. 4,4'-(PENTAMETHYLENEDIOXY)DIBEN 4,4'-(PENTAMETHYLENEDIOXY)DIBENZAMIDE BIS(2-HYDROXYETHANESULFONATE) 4,4'-(Pentamethylenedioxy)-dibenzamidine bis(2-hydroxyethanesulfonate) 4,4'-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate) 4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd 4,4'-(五亚甲基二氧代)二苯甲脒二羟乙基磺酸盐 4,4'-Diamidino-alpha,omega-diphenoxypentane isethionate 4,4'-Diamidinodiphenoxypentane di(beta-hydroxyethanesulfonate) 4,4μ-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate), 1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt) Benambax Benzamidine, 4,4'-(pentamethylenedioxy)di-, bis(beta-hydroxyethanesulfonate) Lomidin Lomidine Lomidine isoethionate M & B 80 PENTAMIDINE DIISETHIONATE PENTAMIDINE ISETHIONATE PENTAMIDINE ISETHIONATE NMDA ANTAG PENTAMIDINE ISETHIONATE SALT PENTAMINE ISETHIONATE PENTAMINIDE ISETIONATE Pentamide Isethionate Pentamidine diisethionate Pentamidine isethionate Pentamidine isethionate salt R.P. 2512 USAF XR-10 WR 4931 p,p'-(Pentamethylenedioxy)dibenzamidine bis(beta-hydroxye p,p'-[Pentamethylenedioxy] dibenzamidine bis[β-hydroxyethanesulfonate] pentamidine isetionate {} {} {} {C 喷他脒羟乙磺酸盐 喷它 |
| MDL Number | MFCD00079213 |
| PubChem Substance ID | 8813 |
| EC Number | 205-424-1 |
| CAS Number | 140-64-7 |
| Chemical Name Translation | 喷他脒羟乙磺酸盐 |
| Merck Number | 13,7192 |
| Wiswesser Line Notation | MUYZR DO5OR DYZUM &WSQ2Q 2 |
| LabNetwork Molecule ID | LN00188471 |
| InChI | InChI=1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6) |
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分类
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Celgene, Excitatory Amino Acids, Inhibits an Enzyme, Ion Channels, Ionotropic Glutamate Receptor Modulators, L - Z, Ligand-Gated Ion Channels, Mechanism of Action, NMDA Antagonists, Neuroscience, Neurotransmission, Neurotransmitters, P-PH, Spectrum of Activity, 抗生素, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Antibacterial, Antibiotics,
相关文献及参考
- [2]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.
- [3]. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.
- [4]. David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.
- [1]. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.
- [1]. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.
- [2]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.
- [3]. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.
- {MCE
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15100 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - woman DOSE/DURATION : 6 mg/kg/D TOXIC EFFECTS : Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 34,441,1974
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 63 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human - man DOSE/DURATION : 21429 ug/kg/5D-I TOXIC EFFECTS : Endocrine - hypoglycemia Skin and Appendages - sweating REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 108,490,1988
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 29500 ug/L REFERENCE : INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 1,103,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 24 mg/kg SEX/DURATION : female 6-11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 163,912,1990
其他信息
- Sigma Aldrich:140-64-7(sigmaaldrich)
- MOL 文件:140-64-7.mol
- MSDS 信息:Pentamidine isethionate(140-64-7).msds
