CAS 64485-93-4 MFCD00079073-sodium (2Z)-N-((6R,7R)-3-(acetoxymethyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(2-imino-2,3-dihydrothiazol-4-yl)-2-(methoxyimino)acetimidate 头孢噻肟钠 TAO{mole}

sodium (2Z)-N-((6R,7R)-3-(acetoxymethyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(2-imino-2,3-dihydrothiazol-4-yl)-2-(methoxyimino)acetimidate 头孢噻肟钠

CAS 64485-93-4 MFCD00079073

化学结构图

SMILES: [Na+].CC(=O)OCC1CS[C@@H]2[C@H](NC(=O)/C(=N\OC)/C3=CSC(N)=N3)C(=O)N2C=1C([O-])=O |&1:9,10|

化学属性

Mol. Formula	C16H16N5NaO7S2
Mol. Weight	477
Melting Point	163

别名和识别编码

Chemical Name	sodium (2Z)-N-((6R,7R)-3-(acetoxymethyl)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)-2-(2-imino-2,3-dihydrothiazol-4-yl)-2-(methoxyimino)acetimidate
CAS Number	64485-93-4
Synonym	Cefotaxime sodium salt 钠盐
PubChem Substance ID	24892923
EC Number	264-915-9
Beilstein Registry Number	5711411
MDL Number	MFCD00079073
Reaxys-RN	6564218
Merck Number	1933
Chemical Name Translation	头孢噻肟钠
Wiswesser Line Notation	T46 ANV ES GUTJ G1OV1 HVO CMVYUNO1&- ET5N CSJ BZ&-NA-
LabNetwork Molecule ID	LN01264947

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group.

安全信息

GHS Symbol

WGK Germany2

Hazard Codes Xn

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSXI0250000

Precautionary statements

P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P352+P333+P313+P362+P364
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P342+P311
P333+P313
P304+P341
P302+P350

Signal word

Safety Statements

Risk Statements

R42/43

Storage condition 0-10 0-10°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6845 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANKHEW Antibiotiki i Khimioterapiya.  Antibiotics and Chemotherapy. (V/O Me
   zhdunarodnaya Kniga, 113095 Moskow, USSR)  V.33-    1988-
   Volume(issue)/page/year: 35(5),25,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   28(Suppl 1),98,1980

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18400 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/pag

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 325 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 21,375,1981