CAS 2438-32-6 MFCD00079046-Dexchlorpheniramine Maleate S-(+)-马来酸氯苯那敏 TAO{mole}

Dexchlorpheniramine Maleate S-(+)-马来酸氯苯那敏

CAS 2438-32-6 MFCD00079046

化学结构图

SMILES: CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)C=CC(=O)O

化学属性

Mol. Formula	C20H23ClN2O4
Mol. Weight	391
Melting Point	112-115 °C(lit.)

别名和识别编码

Chemical Name	Dexchlorpheniramine Maleate
CAS Number	2438-32-6
Synonym	######## (+)-2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (+)-Chlorpheniramine maleate (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt Dexchloropheniramine maleate Dexchlorpheniramine maleate Dextrochlorpheniramine maleate Polaramin Polaramine maleate Poramine maleate S-(+)-Chlorpheniramine maleate S-(+)-Chlorpheniramine maleate salt [γ-(4-chlorophenyl)-pyridine-2-propyl](dimethyl)ammonium hydrogen (Z)-maleate chlormene chlorpheniramine maleate d-Chlorpheniramine maleate g-(4-chlorophenyl)-N,N-dimethyl-2-pyridine propanamine maleate γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate 马来酸右氯苯那敏
MDL Number	MFCD00079046
EC Number	219-450-6
PubChem Substance ID	5281070
Chemical Name Translation	S-(+)-马来酸氯苯那敏
Wiswesser Line Notation	T6NJ BYR DG&2N1&1 &QV1U1VQ -+
LabNetwork Molecule ID	LN00244025
InChI	InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

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产品应用

The S-enantiomer of Chlorpheniramine (C424300). Antihistaminic.

安全信息

WGK Germany3

RTECSUS6504000

GHS Symbol

Precautionary statements

P301+P310

Hazard statements

H301 Toxic if swallowed 吞食有毒

Signal word Danger

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R25 Toxic if swallowed 吞咽有毒

UN Number 2811

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 240 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 124,347,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 188 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,436,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 82 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,436,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 133 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other