Bumetanide 布美他尼
CAS 28395-03-1 MFCD00078949
化学结构图
SMILES: CCCCNC1C=C(C=C(C=1OC1C=CC=CC=1)S(N)(=O)=O)C(O)=O
化学属性
| Mol. Formula | C17H20N2O5S |
|---|---|
| Mol. Weight | 364.45 |
别名和识别编码
| Chemical Name | Bumetanide |
|---|---|
| CAS Number | 28395-03-1 |
| Synonym | 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic Acid 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoic Acid Burinex Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- Burine Ro 10-6338 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid Bumex Fontego Lixil Segurex Lunetoron Bumetanide PF 1593 Fordiuran Bufenox |
| MDL Number | MFCD00078949 |
| PubChem Substance ID | 24278265 |
| EC Number | 249-004-6 |
| Wiswesser Line Notation | ZSWR CVQ FOR& EM4 |
| Beilstein Registry Number | 2185351 |
| Chemical Name Translation | 布美他尼 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecule Alphabetical Index, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Roche, Validus, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Roche, Validus, Voltage-gated Ion Channels
- {SNA} Approved Therapeutics/Drug Candidates, B, Bioactive Small Molecules,
产品应用
- Bumetanide is a diuretic.
相关文献及参考
- Ward, A., et al.: Drugs, 28, 426 (1984),
- Gradeen, C.Y, et al.: J. Anal. Toxicol., 14, 123 (1990),
- Tata, P.N.V., et al.: Anal. Profiles Drug Subs. Excip., 22, 107 (1993),
- Morita, H., et al. Neurosci. Lett. 264 , 65, (1999) 摘要
- Isenring, P. and Forbush, B. J. Biol. Chem. 272 , 24556, (1997) 摘要
- Merck 14 ,1484
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 7,614,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 51(Suppl 6),14,1975
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 7,614,1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 27,1057,1976
