CAS 28981-97-7 MFCD00078881-Alprazolam 阿普唑仑 TAO{mole}

Alprazolam 阿普唑仑

CAS 28981-97-7 MFCD00078881

化学结构图

SMILES: CC1=NN=C2CN=C(C3C=C(Cl)C=CC=3N21)C1C=CC=CC=1

化学属性

Mol. Formula	C17H13ClN4
Mol. Weight	308.79

别名和识别编码

Chemical Name	Alprazolam (CIV), USP
CAS Number	28981-97-7
Synonym	8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine U-31889 Tafil U 31889 D-65MT Xanax Xanor Alplax 阿普唑仑 Esparon D 65MT Tranquinal Cassadan Alprazolam TUS-1 Trankimazin
MDL Number	MFCD00078881
PubChem Substance ID	24891366
EC Number	249-349-2
Wiswesser Line Notation	T B576 BN DNN HN GHJ C1 IR& LG
Beilstein Registry Number	1223125
Chemical Name Translation	阿普唑仑

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分类

A, AA to AL, Alphabetic, Analytical Standards, Analytical/Chromatography, Benzodiazepin Analoga Structure, Chemical Structure, Chromatography, Drugs of Abuse, Forensic and Veterinary Standards
{SA} A, A-AM, AA to AL, Alphabetic, Analytical Standards, Analytical/Chromatography, Approved Therapeutics/Drug Candidates, Benzodiazepin Analoga Structure, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Drugs & Metaboli

产品应用

Controlled substance (depressant). Anxiolytic.

安全信息

RTECSXZ5473000

WGK Germany3

GHS Symbol

Signal word Warning

Hazard statements

H302 Harmful if swallowed 吞食有害

Hazard Codes F,T Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Precautionary statements

P301+P310
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - muscle weakness
   Behavioral - antipsychotic
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K.,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 ug/kg/1D-I
TOXIC EFFECTS :
   Behavioral - euphoria
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 141,1127,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 770 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
REFERENCE :
   CKFRAY Ceskoslovenska Farmacie.  (PNS-Ustredni Expedice a Dovoz Tisku,
   Kafkova 19, 160 00 Prague 6, Czechoslovakia)  V.1-    1952-
   Volume(issue)/page/year: 37,443,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 355 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 8,4695,1980

TYPE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 7 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
                          lactating female 1 week(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   DICPBB Drug Intelligence and Clinical Pharmacy.  (POB 42435, Cincinnati, OH
   45242)  V.3-    1969-  Volume(issue)/page/year: 23,614,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 550 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   7,65,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 195 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JZKEDZ Jitchuken Zenrinsho Kenkyuho.  Central Institute for Experimental
   Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
   Takatsu-ku, Kawasaki 211, Japan)  V.1-    1975-  Volume(issue)/page/year:
   7,79,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 39 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC