5-(N-METHYL-N-ISOBUTYL)AMILORIDE
CAS 96861-65-3 MFCD00078567
化学结构图
SMILES: CN(C1=NC(N)=C(N=C1Cl)C(=O)NC(N)=N)C(C)(C)C
化学属性
| Mol. Formula | C11H18ClN7O |
|---|---|
| Mol. Weight | 299.76 |
别名和识别编码
| Chemical Name | 5-(N-Methyl-N-isobutyl)amiloride |
|---|---|
| Synonym | MIA |
| MDL Number | MFCD00078567 |
| PubChem Substance ID | 24278228 |
| CAS Number | 96861-65-3 |
| Chemical Name Translation |
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分类
- {SA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
- {SNA} A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Ion Channels, M, Monovalent Ion Channels, Sodium Channel Modulators, Voltage-gated Ion Channels, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
- Maidorn, R.P., et al. Br. J. Cancer 67 , 297, (1993) 摘要
- Xiao, X.H., Allen, D.G. Circ. Res. 85 , 723, (1999) 摘要
- Lauro, K.L., et al. Brain Res. 831 , 64, (1999) 摘要
- Coaxum, S.D., et al., Epidermal growth factor activates Na + /H + exchanger in podocytes through a mechanism that involves Janus kinase and calmodulin Biochim. Biophys. Acta 1793 , 1174-81, (2009)
- Tseng, I.C., et al., Matriptase activation, an early cellular response to acidosis J. Biol. Chem. 285 , 3261-70, (2010)
- Hughes, A.L., et al., Regulatory volume increase in epithelial cells isolated from the mouse fourth ventricle choroid plexus involves Na(+)-H(+) exchange but not Na + -K + -2Cl - cotransport Brain Res. 1323 , 1-10, (2010)
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
