CAS 32986-56-4 MFCD00077885-Tobramycin 妥布霉素 TAO{mole}

Tobramycin 妥布霉素

CAS 32986-56-4 MFCD00077885

化学结构图

SMILES: NC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](N)[C@@H]3O)[C@@H](N)C[C@H]2N)[C@@H](N)C[C@H]1O |&1:2,4,6,7,9,11,13,16,18,20,22,25,27,30|

化学属性

Mol. Formula	C18H37N5O9
Mol. Weight	468
Density	1.52
Refractive index	143
Melting Point	178°C
Solubility	Soluble in water (94 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), DMSO (<1 mg/ml at 25 °C), methanol, and PBS (pH 7.2) (~10 mg/ml).,
Stability	对湿度敏感

别名和识别编码

Chemical Name	Tobramycin
CAS Number	32986-56-4
Synonym	Nebramycin 6 1-Epitobramycin Tobrex 3'-Deoxykanamycin B 妥布霉素; 妥布霉素; 硫酸妥布霉素; 托布霉素; 妥布霉素碱; O-3-氨基-3-脱氧-α-O-葡吡喃糖基-(1→6)-O-[2,6-二氨基-2,3,6-三脱氧-α-D-核-己吡喃糖基-(1→4)]-2-脱氧-D-链霉胺 Nebramycin VI Tobradistin O-3-Amino-3-deoxy-?-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-? -D-ribo-hexopyranosyl-(1-4)]-2-deoxy-D-streptamine Tobramycin 妥布霉素 Nebramycin factor 6 Tobralex 妥布霉素，硫酸妥布霉素，托布霉素，妥布霉素碱，O-3-氨基-3-脱氧-alpha-O-葡吡喃糖基-(1→6)-O-[2 3 Obramycin Distobram Tobramax Tobramaxin Deoxykanamycin B 6-三脱氧-alpha-D-核-己吡喃糖基-(1→4)]-2-脱氧-D-链霉胺 Gernebcin 6-二氨基-2
MDL Number	MFCD00077885
Beilstein Registry Number	1357507
EC Number	251-322-5
PubChem Substance ID	87560061
Reaxys-RN	1357507
Merck Number	9490
Chemical Name Translation	妥布霉素
Wiswesser Line Notation	T6OTJ CZ EQ F1Z BO- BL6TJ AZ CQ EZ DO- BT6OTJ CQ DZEQ F1Q
LabNetwork Molecule ID	LN01745230

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产品应用

Tobramycin is an aminoglycoside antibiotic.

安全信息

WGK Germany2

RTECSWK2100000

Storage condition 2-8℃保存。储存温度2-8℃; 充氩保存

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 27,1467,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 445 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIMRBV Journal of International Medical Research.  (Cambridge Medical Pub.
   Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK)  V.1-    1972-
   Volume(issue)/page/year: 2,100,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 27,1467,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 969 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   22,332,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 600 mg/kg
SEX/DURATION            : female 10-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   12,19,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   23,1544,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki,
   Shinagawa-Ku, Tokyo 141, Japan)  V.1-    1953- Volume(issue)/page/year:
   23,1544,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 150 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NKRZAZ Chemotherapy (Tokyo).  (Nippon Kagaku Ryoho

其他信息

妥布霉素属氨基糖苷类，白色或类白色吸湿性粉末。
Tobramycin is an aminoglycoside antibiotic with similar structure to the kanamycins and gentamycins. It is useful for respiratory infection and cystic fibrosis research.