Prostaglandin A1 Prostaglandin

CAS 14152-28-4 MFCD00077858

化学结构图

14152-28-4
SMILES: CCCCC[C@H](O)/C=C/[C@H]1C=CC(=O)[C@@H]1CCCCCCC(O)=O

化学属性

Mol. FormulaC20H32O4
Mol. Weight336

别名和识别编码

Chemical NameA1
Synonym (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid PGA1 PGA(sub 1) PGA(sup 1) PGA1 Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)- Prostaglandin A(sub 1) Prostaglandin A(sup 1) Prostaglandin A1 Prostaglandin E(sup 1)-217
MDL NumberMFCD00077858
PubChem Substance ID24898834
Beilstein Registry Number2003401
CAS Number14152-28-4
Chemical Name TranslationProstaglandin
Wiswesser Line NotationT5V BUTJ D2YQ5 E6VQ
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分类

  • Allium cepa (Onion), Allium sativum (Garlic), Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids, Lipids in Cell Signaling, Nutrition Research, P, Phytochemicals by Plant (Food/Spice/Herb), Prostaglandins
  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Eicosanoids (Prostaglandins, Leukotrienes), Fatty Acyls, Lipids, Nutrition Research,
  • {SNA} Allium cepa (Onion),

相关文献及参考

  • Elia, et al., Induction of ferritin and heat shock proteins by prostaglandin A1 in human monocytes. Evidence for transcriptional and post-transcriptional regulation. Eur. J. Biochem. 264 , 736-45, (1999) 摘要
  • Kikuchi, Y., et al. Cancer Metastasis Rev. 13 , 309, (1994) 摘要
  • Takahashi, et al., Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA. Biochem. J. 335 , 35, (1998) 摘要

安全信息

WGK Germany3
RTECSGY5977900
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   43,513,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 169 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 95,40,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 16 day(s) after conc

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   PRGLBA Prostaglandins.  (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022)
   V.1-    1972-  Volume(issue)/page/year: 1,191,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 169 ug/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   ACATA5 Acta Anatomica.  (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY
   10003)  V.1-    1945-  Volume(issue)/page/year: 95,40,1976

TYPE OF TEST            :

系列性分类


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