Monensin Sodium Salt 莫能霉素钠
CAS 22373-78-0 MFCD00077826
化学结构图
SMILES: [Na+].C[C@]1(CCC2(C[C@H](O)[C@@H](C)[C@H](O2)[C@@H](C)[C@@H](OC)[C@H](C)C([O-])=O)O1)[C@H]1CC[C@](CC)(O1)[C@@H]1O[C@H](C[C@@H]1C)[C@H]1O[C@@](O)(CO)[C@H](C)C[C@@H]1C
化学属性
| Mol. Formula | C36H61NaO11 |
|---|---|
| Mol. Weight | 693 |
| Melting Point | 267-269 |
别名和识别编码
| Chemical Name | Monensin Sodium Salt |
|---|---|
| Synonym | Monensin 钠盐 Coban 45 |
| CAS Number | 22373-78-0 |
| PubChem Substance ID | 24896992 |
| EC Number | 244-941-7 |
| Beilstein Registry Number | 4122200 |
| MDL Number | MFCD00077826 |
| Chemical Name Translation | 莫能霉素钠 |
| Wiswesser Line Notation | T6OXTJ DQ E1 FY1&YO1&Y1&VQ B-& BT5OXTJ E1 E- ET5OTJB2 B- BT5OTJ |
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分类
- {SNA} Additional Standards, Analytical Standards, Antibacterial, Antibiotics A to Z, Antibiotics G-M, Antibiotics Standards, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antiparasitic / Antiprotozoal / Anthelminthic, Bactericidal, Chemical Structure, Chemical Structure Class, Chromatography, Clinical Standards, E numbers (Food Additives), E700–E799 (antibiotics), E714, Food & Beverage Standards, Food and Cosmetic Component Standards, Interferes with Cell Membrane Permeability (Ionophores), L - Z, MLS, Mechanism of Action, Pharmaceuticals
相关文献及参考
- Callaway, T.R., et al., Selection of a highly monensin-resistant Prevotella bryantii subpopulation with altered outer membrane characteristics. Appl. Environ. Microbiol. 65 , 4753-4759, (1999) 摘要
- Wang, X.D., et al., Phospholipase C activation by Na + /Ca 2+ exchange is essential for monensin-induced Ca 2+ influx and arachidonic acid release in FRTL-5 thyroid cells. J. Investig. Med. 47 , 388-396, (1999) 摘要
- Nebbia, C., et al., Oxidative metabolism of monensin in rat liver microsomes and interactions with tiamulin and other chemotherapeutic agents: evidence for the involvement of cytochrome P-450 3A subfamily. Drug Metab. Dispos. 27 , 1039-1044, (1999) 摘要
- Dmitrovic, J., and Durden, D.A., A New Approach To The Analysis Of Nicarbazin And Ionophores In Eggs By HPLC/MS/MS. J. AOAC Int. 94 , 428-35, (2011) 摘要
安全信息
GHS Symbol
- H300 Fatal if swallowed 吞食致命
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - pig DOSE/DURATION : 17 mg/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 58,1512,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc
{hTYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 58,1512,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 145 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
MBIID4 MBI, Mediko Biologicheskaya Informatsiya. Medical-Biological
Information. ("Ivana Vazova" No. 3, Sofia 1000, Bulgaria) 1967-
Volume(issue)/page/year: (3),3,1984