2',3'-Dideoxyinosine 地丹诺辛
CAS 69655-05-6 MFCD00077728
化学结构图
SMILES: OC[C@@H]1CC[C@@H](O1)N1C=NC2C(=O)NC=NC1=2
化学属性
| Mol. Formula | C10H12N4O3 |
|---|---|
| Mol. Weight | 236 |
| Melting Point | 193 |
| TSCA | No |
别名和识别编码
| Chemical Name | 2',3'-Dideoxyinosine |
|---|---|
| CAS Number | 69655-05-6 |
| Synonym | 2',3'-Dideoxy-inosine Didanosine NSC 612049 Videx ddI ddI ddIno 地丹诺辛 |
| MDL Number | MFCD00077728 |
| Beilstein Registry Number | 3619529 |
| PubChem Substance ID | 87559876 |
| Merck Number | 3098 |
| Chemical Name Translation | 地丹诺辛 |
| Reaxys-RN | 3619529 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Nucleotides
- {SNA} AIDS and Viral Research Reagents, Core Bioreagents, Immune Cell Signaling and Blood, Immune System Regulation, Nucleosides and Nucleotides, Research Essentials, 细胞信号转导和神经科学, 细胞生物学
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Bases & Related Reagents,
- {SNA} AIDS and Viral Research Reagents, Bioactive Small Molecules, Cell Biology,
产品应用
- Used as an antiviral.
相关文献及参考
- Dahlberg, J.E., et al.: Proc. Nat. Acad. Sci. U.S.A., 83, 1911 (1986)
安全信息
GHS Symbol
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 2340 mg/kg/34W-I TOXIC EFFECTS : Liver - fatty liver degeneration Liver - jaundice, cholestatic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 115,283,1991
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year:
TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 100 mg/L REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,197,1992
TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 6 gm/kg/3D (Intermittent) REFERENCE : EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 18,168,1991
