CAS 486-56-6 MFCD00077696-(-)-Cotinine (-)-可替宁 TAO{mole}

(-)-Cotinine (-)-可替宁

CAS 486-56-6 MFCD00077696

化学结构图

SMILES: CN1C(=O)CC[C@H]1c1cccnc1

化学属性

Mol. Formula	C10H12N2O
Mol. Weight	176
Boiling Point	250
Melting Point	40-42
Flash Point	>110°(230°F)
TSCA	No

别名和识别编码

Chemical Name	(-)-Cotinine
CAS Number	486-56-6
Alfabeta Name	COTININE ()--
MDL Number	MFCD00077696
Synonym	(-)-Cotinine (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone (S)-(-)-1-Methyl-5-(3-pyridiyl)-2- (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone, S()-1-Methyl-5-(3-pyridyl)-2-pyrrolidone (S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮 S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮 (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone, S(−)-1-Methyl-5-(3-pyridyl)-2-pyrrolidone 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (S)- Cotinine Scotine
PubChem Substance ID	854019
EC Number	207-634-9
Beilstein Registry Number	83099
Merck Number	14,2553
Chemical Name Translation	(-)-可替宁
LabNetwork Molecule ID	LN00168073
InChI	InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1

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分类

1694 Pharmaceuticals & Personal Care Products, Alkaloids, Alphabetic, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, C, CI-CY, CO - CZ, Cell Biology, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, EPA, Forensic and Veterinary Standards, Method Specific, Others, Solutions
{SNA} 1694 Pharmaceuticals & Personal Care Products, Analytical Standards, Analytical/Chromatography, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Sig

产品应用

A major metabolite of Nicotine (N412450) in humans. Carcinogen.

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany3

Hazard Codes F,T

Hazard statements

H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSGN1925500

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P302+P352
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

Risk Statements

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 930 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 137,313,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1604 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 137,313,1962