Bromotripyrrolidinophosphonium hexafluorophosphate 三吡咯烷基溴化鏻六氟磷酸盐

CAS 132705-51-2 MFCD00077412

化学结构图

132705-51-2
SMILES: F[P-](F)(F)(F)(F)F.Br[P+](N1CCCC1)(N1CCCC1)N1CCCC1

化学属性

Mol. FormulaC12H24BrF6N3P2
Mol. Weight466
TSCANo
Density1.422
Melting Point>100°C
SolubilityDMF: 0.4 g/mL, clear
Stability对湿度敏感

别名和识别编码

Chemical NameBromotripyrrolidinophosphonium hexafluorophosphate
CAS Number132705-51-2
Alfabeta NameBROMOTRIPYRROLIDINYLPHOSPHONIUMHEXAFLUOROPHOSPHATE V1(())--
MDL NumberMFCD00077412
Synonym BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE PyBroP\(rg BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXFLUOROPHOSPHATE PyBroP PYBROP(TM) Bromo-tris-pyrrolidino-phosphonium hexafluorophosphat Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97% Pybrop(Bromo-Tris-PyrrolidinophosphoniumHexafluorophosphate) 溴-三吡咯烷基磷代六氟磷酸酯 PYBROP(R) Bromotri(pyrrolidin-1-yl)phosphoniumhexafluorophosphate PYBROP 三吡咯烷基溴化六氟磷酸盐 BROMOTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE PyBroP® Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate ,97% Pyrrolidine phosphorus complex 三吡咯烷基溴化鏻六氟磷酸盐
PubChem Substance ID160871368
Beilstein Registry Number6842340
EC Number000-000-0
Chemical Name Translation三吡咯烷基溴化鏻六氟磷酸盐
Reaxys-RN6842340
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分类

  • {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

产品应用

  • 多肽缩合剂，适宜于烃基双取代的氨基酸，用于Depsipeptide的合成。

相关文献及参考

  • 1. Vassiliki Theodorou, et al Tetrahedron 67 , 5630-5634, (2011)
  • 2. Fu-An Kang, et al Chem. Commun. 46 , 1347-1349, (2010)
  • 3. Fu-An Kang, et al J. Am. Chem. Soc. 130 , 1130-11302, (2008)
  • 4. Jordi Alsina, et al Lett. Pept. Sci. 6 , 243-245, (1999)
  • 5. J. Coste et al. J. Org. Chem. 59 , 2437, (1994)
  • 6. T. Kurome et al. Tetrahedron 52 , 4327, (1996)
  • Efficient peptide coupling agent for N-methylated amino esters for which coupling with a number of conventional reagents has proved ineffective or slow, and giving superior results to 1H-Benzotriazol-1-yl­oxytri(1-pyrrolidinyl)­phosphonium hexafluorophosphate, B25251, in this type of reaction: J. Org. Chem., 59, 2437 (1994). See Appendix 6.
  • Can also be used to activate formamides, e.g. reaction of DMF with primary amines to yield formamidines: Tetrahedron Lett., 40, 5487 (1999).

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Hazard Codes C Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Danger Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R34 Causes burns 会导致灼伤
Storage condition Moisture Sensitive -20°C <0°C 储存温度 -20°C

其他信息

  • Acros Organics:溴-三吡咯烷基磷代六氟磷酸酯 Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate, 97%(132705-51-2)
  • 存储注意事项:氮气保护;湿度敏感
  • MOL 文件:132705-51-2.mol
  • Alfa Aesar:溴-三吡咯烷基磷代六氟磷酸酯,97% Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97%(132705-51-2)
  • 检测方法:HPLC
  • 产品分类:多肽试剂.
  • F:10-21
  • 外观:白色或灰白色结晶.
  • Sigma Aldrich:132705-51-2(sigmaaldrich)
  • 敏感性:Moisture Sensitive
  • PYBROP(三吡咯烷基溴化鏻六氟磷酸盐,)价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 302130050 PYBROP(三吡咯烷基溴化鏻六氟磷酸盐,) Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate 97% 5 GR 1609元 2010/06/21 302130250 PYBROP(三吡咯烷基溴化鏻六氟磷酸盐,) Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate 97% 25 GR 6988元 2010/05/25 L19384 溴-三吡咯烷基磷代六氟磷酸酯, 97% Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97% 5g 1400元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Phosphorus Compounds 磷化合物
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosgene Derivatives - Coupling
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Phosphonium/Uronium/Formamidinium - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Phosphonium/Uronium/Formamidinium - Peptide Coupling
  1. Chemical Synthesis 化学合成
  2. Catalysis and Inorganic Chemistry 催化剂和无机化学
  3. 医药合成催化剂

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