Sodium 2-((2,6-Dichloro-3-Methylphenyl)Amino)Benzoate 2-((2,6-二氯-3-甲基苯基)氨基)苯甲酸钠
CAS 6385-02-0 MFCD00077376
化学结构图
SMILES: Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl.[Na+]
化学属性
| Mol. Formula | C14H10Cl2NNaO2 |
|---|---|
| Mol. Weight | 318.13 |
别名和识别编码
| Chemical Name | Sodium 2-((2,6-Dichloro-3-Methylphenyl)Amino)Benzoate |
|---|---|
| Synonym | 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt CI 583 Meclofenamate sodium Meclofenamic acid sodium salt Meclomen Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate Sodium meclofenamate Sodium meclophenamate |
| MDL Number | MFCD00077376 |
| PubChem Substance ID | 4038 |
| CAS Number | 6385-02-0 |
| EC Number | 228-983-3 |
| Reaxys-RN | 4222941 |
| Merck Number | 5779 |
| Chemical Name Translation | 2-((2,6-二氯-3-甲基苯基)氨基)苯甲酸钠 |
| Wiswesser Line Notation | OVR BMR BG FG C1 &-NA- |
| LabNetwork Molecule ID | LN01287482 |
| InChI | InChI=1S/C14H11Cl2NO2.Na/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;/h2-7,17H,1H3,(H,18,19);/q;+1/p-1 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, L to O, Lipids in Cell Signaling, Lipoxygenase, Lipoxygenase (5-) and cyclooxygenase, M, Pfizer Compounds, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} Approved Therapeutics/Drug Candidates, Arachidonic Acid Cascade, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhib
相关文献及参考
- [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.
- [3]. Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.
- Boctor, A.M., et al. Prostaglandins Leukotrienes Med. 23 , 229, (1986)
- [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
- [1]. Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.
- [2]. Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.
- [3]. Huang Y, et al. Meclofenamic acid selectively in
安全信息
- H302 Harmful if swallowed 吞食有害
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
GHS Symbol
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 120 mg/kg/6W TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, allergic (after systemic exposure) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,631,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 521 mg/kg/78W-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954- Volume(issue)/page/year: 82,1320,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 3 mg/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase REFERENCE : JRHUA9 Journal of Rheumatology. (920 Yonge St., Suite 608, Toronto, Ont., Canada) V.1- 1974- Volume(issue)/page/year: 10,169,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 324 mg/kg
SEX/DURATION : female 15 day(s) pre-mating
female 1-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
5,665,1985TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 522 mg/kg SEX/DURATION : female 15 day(s) pre-mating - 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,665,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 112 mg/kg
SEX/DURATION : female 14 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
15,46,1969TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 261 mg/kg SEX/DURATION : female 15-22 day(s) after conception
