ALPHA-ANF(1-28), HUMAN
CAS 91917-63-4 MFCD00076226
化学结构图
SMILES: CSCC[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)CNC(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC1=O)[C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO
化学属性
| Mol. Formula | C127H203N45O39S3 |
|---|---|
| Mol. Weight | 3080.44 |
别名和识别编码
| Chemical Name | Atrial Natriuretic Peptide human |
|---|---|
| Synonym | Atriopeptin-28 (human) Triopeptin (human alpha-component) SUN-4936 ANF 1-28 hANF alpha-Atriopeptin (human) Carperitide Human atriopeptin(1-28) Human atriopeptin(99-126) alpha-Human atrial natriuretic hormone |
| MDL Number | MFCD00076226 |
| PubChem Substance ID | 24890580 |
| CAS Number | 89213-87-6 |
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分类
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Guanylate Cyclase Activators, Miscellaneous Peptides, Natriuretic Peptides, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology
- Cell Biology, Cell Signaling and Neuroscience, Guanylate Cyclase Activators, Miscellaneous Peptides, Natriuretic Peptides, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology
- {SNA} Guanylate Cyclase Activators, Miscellaneous Peptides, Natriuretic Peptides, Neuropeptides, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. T T Tan, et al. ANF(1-28) is a potent suppressor of pro-opiomelanocortin (POMC) mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells. J Endocrinol. 1994 Nov;143(2):R1-4.
- [3]. D M Pollock, et al. Beneficial effect of the ANF analog A68828 on recovery from ischemic acute renal failure. Ren Fail. 1992;14(2):141-6.
- Gonzalez Bosc, L.V., Effects of atrial natriuretic peptide in the gut. Peptides 21 , 875, (2000) 摘要
- Palluk, R., et al., Atrial natriuretic factor. Life Sci. 36 , 1415-1425, (1985)
- Potter, L.R. and Hunter, T., Structural and functional evolution of the natriuretic peptide system in vertebrates. Int. Rev. Cytol. 194 , 1, (2000)
- Potter, L.R., and Hunter, T., Identification and characterization of the phosphorylation sites of the guanylyl cyclase-linked natriuretic peptide receptors A and B. Methods 19 , 506-520, (1999) 摘要
- Thibault, G., et al., Regulation of natriuretic peptide secretion by the heart. A
安全信息
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE : 840 mg/kg
SEX/DURATION : male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 44,485,1992TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE : 110 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - behavioral REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 44,495,1992
