Isoliquiritigenin 异甘草素

CAS 961-29-5 MFCD00075907

化学结构图

961-29-5
SMILES: O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O

化学属性

Mol. FormulaC15 H12 O4
Mol. Weight256.25
Melting Point206-210°C
TSCANo
Density1.384
Stability对空气和热敏感,易吸潮
Appearance powder
SolubilityH2O: <;0.1 mg/mL

别名和识别编码

Chemical NameIsoliquiritigenin
CAS Number961-29-5
Synonym (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 4,2′,4′-Trihydroxychalcone (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 4,2',4'-Trihydroxychalcone (E)-1-(2,4-二羟基苯基)-3-(4-羟基苯基)-2-丙烯-1-酮 (E)-2',4,4'-Trihydroxychalcone 2',4',4-trihydroxychalcone 2',4,4'-三羟基查尔酮;(E)-1-(2,4-二羟基苯基)-3-(4-羟基苯基)-2-丙烯-1-酮 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (E)- 2’,4,4’-trihydroxy-chalcon 4,2',4'-三羟基查耳酮 4,2,4-Trihydroxychalcone 4,2′,4′-Trihydroxychalcone 4,4’-trihydroxychalcone(e)-2 6'-deoxychalcone GU 17 GU-17 ISOLIQUIRITIGENIN(P) ISOLIQUIRTEGENIN (2',4,4'-TRIHYDROXYCHAL ISOLIQUIRTIGENIN Isoliquiritigenin {} {} {} {} {} {} {} {
MDL NumberMFCD00075907
PubChem Substance ID638278
Reaxys-RN1914296
Chemical Name Translation异甘草素
Beilstein Registry Number1914296
Wiswesser Line NotationQR CQ DV1U1R DQ
LabNetwork Molecule IDLN00382049
InChIInChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
Canonical SMILESO=C(C1=CC=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
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分类

  • Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, I
  • {SNA} Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, I, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 生物活性小分子, 细胞信号转导和神经科学,
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, I, Phytochemicals in Herbal Medicine or Traditional Chinese Medicine (TCM), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 营养研究
  • {SN

产品应用

  • 可溶性鸟苷酸环化酶（guanylyl cyclase）激活剂。具有抗肿瘤活性

相关文献及参考

  • [2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9.
  • [3]. Zhang X. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890.
  • [4]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.
  • [5]. Traboulsi H, et al. The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection. Antimicrob Agents Chemother. 2015 Oct;59(10):6317-27.
  • Agrawal, R., et al.: Food Chem. Toxicol., 36, 975 (1998),
  • Baba, M., et al.: Biol. Pharm. Bull., 25, 247 (2002),
  • Chowdhury, S., et al.: Anticancer Res., 25, 2055 (2005),
  • Tawata, et al., Anti-platelet action of isoliquiritigeninan ald

安全信息

RTECSFL7080000
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition +4°C 0-10 0-10°C 2-8°C 4℃ Light Sensitive & Hygroscopic 储存温度2-8℃,充氩储存 易吸潮,2-8℃避光保存
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
GHS Symbol 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4898890

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4898890

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,401,1981

其他信息

  • MOL 文件:961-29-5.mol
  • Alfa Aesar:4,2',4'-三羟基查耳酮,97% 2',4,4'-Trihydroxychalcone, 97%(961-29-5)
  • 对光敏感，易吸潮
  • Sigma Aldrich:961-29-5(sigmaaldrich)
  • color:yellow to orange
  • 异甘草素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 H26920 4,2',4'-三羟基查耳酮, 97% 2',4,4'-Trihydroxychalcone, 97% 5g 3052元 2010/05/25 H26920 4,2',4'-三羟基查耳酮, 97% 2',4,4'-Trihydroxychalcone, 97% 1g 994元
  • 敏感性:Light Sensitive & Hygroscopic
  • 用途一:用作化妆品助剂、食品添加剂等

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Guanylyl Cyclase Activators - Cyclic Nucleotide Metabolism
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. G Proteins and Cyclic Nucleotides - Cell Signaling and Neuroscience
  5. Cyclic Nucleotide Metabolism - G Proteins and Cyclic Nucleotides
  6. Guanylyl Cyclase Activators - Cyclic Nucleotide Metabolism
  1. Medical Research Areas
  2. Metabolism
  3. Aldose Reductase  (醛糖还原酶)

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