Piperlongumine (E)-1-(3-(3,4,5-三甲氧基苯基)丙烯酰基)-5,6-二氢吡啶-2(1H)-酮
CAS 20069-09-4 MFCD00075706
化学结构图
SMILES: COC1C=C(/C=C/C(=O)N2CCC=CC2=O)C=C(OC)C=1OC
化学属性
| Mol. Formula | C17 |
|---|---|
| Mol. Weight | 317 |
| Melting Point | 123.0 - 127.0 |
别名和识别编码
| Chemical Name | Piperlongumine |
|---|---|
| CAS Number | 20069-09-4 |
| Synonym | (E)-1-[3-(3,4,5-Trimethoxyphenyl)acryloyl]-5,6-dihydropyridin-2(1H)-one, 5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-trans-2-propenyl]-2(1H)-pyridinone 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-Pyridinone Piplartin Piplartine 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-Pyridinone 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone Piperlongumine Piplartin Piplartine |
| MDL Number | MFCD00075706 |
| Beilstein Registry Number | 1503970 |
| Chemical Name Translation | (E)-1-(3-(3,4,5-三甲氧基苯基)丙烯酰基)-5,6-二氢吡啶-2(1H)-酮 |
| PubChem Substance ID | 354333528 |
| Reaxys-RN | 1503970 |
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分类
- Pharmaceuticals
- Heterocycles
- {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, P, Substrates, Inducers, Inhibitors
- Intermediates & Fine Chemicals
- Aromatics
- {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, PI-PZ, Substrates, Inducers, Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer
相关文献及参考
- [2]. Wu X, e,t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119(12):10358-10364
- Beretz, A., et al.: Planta Med., 57, 68 (1991),
- Lee, K., et al.: Pharmacol. Res., 53, 265 (2006),
- Lee, S., et al.: J. Microbiol. Biotechnol., 12, 679 (2002),
- [1]. Karki K, et al. Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.
- [1]. Karki K, et al. Piperlongumine Induces Reactive Oxygen Species (ROS)-Dependent Downregulation of Specificity Protein Transcription Factors.
- [2]. Wu X, e,t al. Piperlongumine inhibits angiotensin II-induced extracellular matrix expression in cardiac fibroblasts. J Cell Biochem. 2018 Dec;119(12):10358-10364
安全信息
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