Canrenone 坎利酮
CAS 976-71-6 MFCD00071735
化学结构图
SMILES: CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC21CCC(=O)O1
化学属性
| Mol. Formula | C22H28O3 |
|---|---|
| Mol. Weight | 340.50 |
别名和识别编码
| Chemical Name | Canrenone |
|---|---|
| MDL Number | MFCD00071735 |
| CAS Number | 976-71-6 |
| Synonym | 坎利酮; 刊利酮 Phanurane Aldadiene 11614 R.P SC 9376 Canrenone Spirolactone SC 14266 |
| EC Number | 213-554-5 |
| Chemical Name Translation | 坎利酮 |
| Beilstein Registry Number | 0046602 |
| PubChem Substance ID | 13789 |
| InChI | InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1 |
| LabNetwork Molecule ID | LN00190521 |
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相关文献及参考
- [2]. Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124(2):504-20.
- [3]. Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh). 1979 Jan;90(1):147-56.
- [1]. Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277(2):139-49.
- [1]. Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277(2):139-49.
- [2]. Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroentero
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,36,1990
