8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
CAS 51116-01-9 MFCD00070128
化学结构图
SMILES: [Na+].NC1NC(=O)C2N=C(Br)N([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C=2N=1
化学属性
| Mol. Formula | C10H10BrN5NaO7P |
|---|---|
| Mol. Weight | 446 |
别名和识别编码
| Chemical Name | 8-Bromoguanosine 3',5'-cyclic monophosphate sodium salt |
|---|---|
| Synonym | 8-Br-cGMP 8-Br-cGMP 8-Bromo-cyclic GMP 8-Bromo-cyclic GMP 8-Bromoguanosine-3',5'-cyclomonophosphate sodium salt |
| MDL Number | MFCD00070128 |
| PubChem Substance ID | 24278021 |
| CAS Number | 51116-01-9 |
| EC Number | 256-993-8 |
| Beilstein Registry Number | 8378760 |
| Chemical Name Translation | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 |
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资金保障
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分类
- {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
- B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase G (PKG),
相关文献及参考
- Choi, J., and Farley, J.M., Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. J. Pharmacol. Exp. Ther. 285 , 588-594, (1998) 摘要
- Francis, S.H., et al., Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol. Pharmacol. 34 , 506-517, (1988) 摘要
- Garg, U.C., and Hassid, A., Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators. Am. J. Physiol. 257 , F60-F66, (1989) 摘要
- Garg, U.C., and Hassid, A., Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J. Clin. Invest. 83 , 1774-1777, (1989) 摘要
- Prakash, Y.S., et al., Nitric oxide inhibits ACh-induced intracellular calcium oscillations in porcine tracheal smooth muscle. Am. J. Physiol. 272 , L588-L596, (1997) 摘要
- Ruth, P., et al., The activation of expressed cGMP-dependent protein kinase isozymes Iα and Iβ is determined by the different amino-termini. Eur. J. Biochem. 202 , 1339, (1991) 摘要
安全信息
GHS Symbol
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
