CAS 520-85-4 MFCD00069474-Medroxyprogesterone 甲羟孕酮 TAO{mole}

Medroxyprogesterone 甲羟孕酮

CAS 520-85-4 MFCD00069474

化学结构图

SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C

化学属性

Mol. Formula	C22H32O3
Mol. Weight	344.50
Melting Point	215.0 to 220.0 deg-C

别名和识别编码

Chemical Name	Medroxyprogesterone
Synonym	(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17 alpha Hydroxy 6 alpha Methylprogesterone 17 alpha-Hydroxy-6 alpha-Methylprogesterone 17-Hydroxy-6-methyl-4-pregnene-3,20-dione 17-hydroxy-6-methyl-20-dion(6-alpha)-pregn-4-ene- 17-hydroxy-6-methyl-20-dion(6alpha)-pren-4-ene- 17-hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione 17ALPHA-HYDROXY-6ALPHA-METHYL-4-PREGNENE-3,20-DIONE 17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17α-羟基-6α-甲基-4-孕烯-3,20-二酮 17α-羟基-6α-甲基孕酮 6α-甲基-5-孕甾烯-17α-醇-3,20-二酮 6-二氢甲地孕酮 4-PREGNEN-6-ALPHA-METHYL-17-OL-3,20-DIONE 6-ALPHA-METHYL-17-HYDROPROGESTERONE 6-DIHYDROMEGESTROL 6-alpha-Methyl-17-alpha-hydroxyprogesterone 6ALPHA-METHYL-17ALPHA-H 6ALPHA-METHYL-5-PREGNEN-17ALPHA-OL-3,20-DIONE Adgyn Medro Medroxyprogesteron {PubChem}
MDL Number	MFCD00069474
PubChem Substance ID	10631
Beilstein Registry Number	2510965
CAS Number	520-85-4
EC Number	208-298-6
Chemical Name Translation	甲羟孕酮
Merck Number	5793
Wiswesser Line Notation	L E5 B666 OV MUTJ A1 E1 FV1 FQ K1
Reaxys-RN	2510965
LabNetwork Molecule ID	LN01287488
InChI	InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

分类

{SNA} APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, Bioactive Small Molecules, Cell Biology, Chromatography, Clinical Standards, Hormones, M, MEA - MES, Medroxyprogesteron, Neats and Solutions, Pharma, Pharmaceutical Standards
{SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, M, Progesterone, Steroid H

安全信息

RTECSTU5300000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P318
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

Hazard Codes Xn

WGK Germany3

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves

Signal word

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R48 Danger of serious damage to health by prolonged exposure 长期接触有严重损害健康的危险

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 6 mg/kg/13W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - sensory change involving peripheral nerve
   Behavioral - hallucinations, distorted perceptions
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 163,51,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 625 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 12,445,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press,
   1965  Volume(issue)/page/year: -,57,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 17-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   ECJPAE Endocrinologia Japonica.  (Japan Pub. Trading Co., Ltd., POB 5030,
   Tokyo International, Tokyo, Japan)  V.1-    1954-  Volume(issue)/page/year:
   24,77,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1120 mg/kg
SEX/DURATION            : male 16 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   acce

其他信息

MOL 文件:520-85-4.mol
Sigma Aldrich:520-85-4(sigmaaldrich)