N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride N-(2-(((5-((二甲氨基)甲基)呋喃-2-基)甲基)硫代)乙基)-N'-甲基-2-硝基乙烯-1,1-二胺盐酸盐
CAS 66357-59-3 MFCD00069339
化学结构图
SMILES: [2H]C([2H])([2H])N(CC1=CC=C(CSCCN/C(=C/[N+]([O-])=O)/NC)O1)C([2H])([2H])[2H]
化学属性
| Mol. Formula | C13H23ClN4O3S |
|---|---|
| Mol. Weight | 351 |
| Melting Point | ca 134° dec. |
| TSCA | No |
别名和识别编码
| Chemical Name | N-(2-(((5-((Dimethylamino)methyl)furan-2-yl)methyl)thio)ethyl)-N'-methyl-2-nitroethene-1,1-diamine hydrochloride |
|---|---|
| Synonym | 4-Propyl-benzoic acid 4-cyano-phenyl ester AH 19065 ME3N RO-CM-1430 Ranidil Ranigast Ranitidine hydrochloride ZLI-2279 Zantac {} {} {} {uni_hamburg} |
| MDL Number | MFCD00069339 |
| PubChem Substance ID | 87575630 |
| EC Number | 266-333-0 |
| CAS Number | 66357-59-3 |
| Merck Number | 8110 |
| Chemical Name Translation | N-(2-(((5-((二甲氨基)甲基)呋喃-2-基)甲基)硫代)乙基)-N'-甲基-2-硝基乙烯-1,1-二胺盐酸盐 |
| Reaxys-RN | 4342707 |
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分类
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards P - R
- {SNA} 1694 Pharmaceuticals & Personal Care Products, Method and Regulation Specific, Analytical Standards, Analytical/Chromatography, Antagonists, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, EPA, Enzymes, Inhibitors, and Substrates, GPCR Modulators, GPCR Proteins, Modulators and Antibod
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ester; 1fragment
相关文献及参考
- [2]. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.
- [3]. Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.
- Short: IV/7b Title: Liquid Crystals: Two-Ring Systems with Bridging Group Author: Vill, V. Editor: Thiem, J. Source: Landolt-Börnstein, New Series Volume: IV/7b Year: 1992 Keyword: organic compounds; enthaly of fusion; melting point; phase transition; liquid crystals; glass transition ISBN: 3-540-55504-8 ISBN: 978-3-540-55504-9 Internet Resource: DOI:10.1007/b46099 RefComment: 10 figs., VIII, 653 pages.
- Short: LC Title: LiqCryst 4.6 - Database of Liquid Crystals Author: Vill, V. Year: 2005 Keyword: Flüssigkristalle; LCD; Phasenumwandlung Internet Resource: ht
安全信息
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H303 May be harmfully swallowed 吞食可能有害
TYPE OF TEST : TDLo - Low
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1530 mg/kg TOXIC EFFECTS : Details of toxic effects not reported ot
{TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 2400 mg/kg/43W-I TOXIC EFFECTS : Behavioral - coma Cardiac - pulse rate Skin and Appendages - sweating REFERENCE : AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 139,442,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 85 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8(Suppl 1),1,1983
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Multiple routes SPECIES OBSERVED : Human - woman DOSE/DURATION : 174 mg/kg/33D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - interstitial nephritis REFERENCE : AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981- Volume(issue)/page/year: 22,333,1993
GHS Symbol
