CAS 113-92-8 MFCD00069225-Chlorpheniramine Maleate 马来酸氯苯那敏 TAO{mole}

Chlorpheniramine Maleate 马来酸氯苯那敏

CAS 113-92-8 MFCD00069225

化学结构图

SMILES: CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)/C=C\C(=O)O

化学属性

Mol. Formula	C16H19ClN2.C4H4O4
Mol. Weight	391
Melting Point	130-135
TSCA	Yes
Solubility	DMSO 78 mg/mL Water 78 mg/mL Ethanol 78 mg/mL

别名和识别编码

Chemical Name	Chlorpheniramine Maleate
CAS Number	113-92-8
Synonym	(±)-Chlorpheniramine maleate salt (±)-Chlorpheniramine maleate salt 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylamino 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat 1-p-Chlorophenyl-1 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benz 2-[p-Chloro-?-(2-dimethyl-aminoethyl)benzyl]p Allergisan Alunex C-Meton CHLORPHENAMINE MALEATE Chlor-tripolon Chloroprophenpyridamine maleate Chlorphenamine hydrogen maleate; 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleat Ibioton LABOTEST-BB LT00134667 Polaronil Pyridamal-100 al c-meton chlormene dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate {} {Chemicalbook} {} {} {} {} {Chemica 扑尔敏氯苯
MDL Number	MFCD00069225
PubChem Substance ID	5281068
EC Number	204-037-5
Reaxys-RN	4117059
Merck Number	2180
Chemical Name Translation	马来酸氯苯那敏
Wiswesser Line Notation	T6NJ BYR DG&2N1&1 &OV1U1VO
Beilstein Registry Number	4117059
LabNetwork Molecule ID	LN00831818
InChI	InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

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分类

{SA} Antagonists, Cell Biology, Cell Signaling and Neuroscience, Histaminergics, Neuroscience, Neurotransmission, Neurotransmitters
{SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecule Alphabetical Index, C-CH, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,

产品应用

Antihistaminic.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P312+P330
P308+P311
P308+P313
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger Warning {} {} {} {} {} {} {TCI}

Hazard statements

H302 Harmful if swallowed 吞食有害
H301 Toxic if swallowed 吞食有毒

Hazard Codes 6.1 T Xn

RTECSUS6503000

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R25 Toxic if swallowed 吞咽有毒

UN Number 2811 UN 2811 6.1/PG 3

Storage condition 储存温度-20°C

Packing GroupIII

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,313,1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26100 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,537,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76700 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955

{haz

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 125 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-317,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-317,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 420 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,188,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4200 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,188,1968

其他信息

MOL 文件:113-92-8.mol
生产方法:由氯屈米通与顺丁烯二酸成盐而得。
RTECS号:US6504000
用途:用作抗过敏药
马来酸氯苯那敏价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 C0873 马来酸氯苯那敏 Chlorpheniramine Maleate 25G 539元 2010/05/25 B25238 马来酸氯苯那敏,99% Chlorpheniramine maleate, 99% 5g 344元 2010/05/25 B25238 马来酸氯苯那敏,99% Chlorpheniramine maleate, 99% 25g 792元
EPA化学物质信息:2-Pyridinepropanamine, .gamma.-(4-chlorophenyl)-N, N-dimethyl-, (2Z)-2-butenedioate (1:1)(113-92-8)
(±)-Chlorpheniramine maleate salt
PackingGroup:III
HazardClass:6.1(b)
图谱信息:马来酸氯苯那敏(113-92-8)质谱(MS) 马来酸氯苯那敏(113-92-8)核磁图( 1 HNMR) 马来酸氯苯那敏(113-92-8)红外图谱(IR1) 马来酸氯苯那敏(113-92-8)核磁图( 13 CNMR) 马来酸氯苯那敏(113-92-8)红外图谱(IR2)