CAS 14028-44-5 MFCD00069210-Amoxapine 阿莫沙平 TAO{mole}

Amoxapine 阿莫沙平

CAS 14028-44-5 MFCD00069210

化学结构图

SMILES: ClC1=CC2C(=NC3C=CC=CC=3OC=2C=C1)N1CCNCC1

化学属性

Mol. Formula	C17H16ClN3O
Mol. Weight	313.79
TSCA	No
Melting Point	178.0 to 182.0 deg-C

别名和识别编码

Chemical Name	Amoxapine
CAS Number	14028-44-5
Synonym	2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine 2-Chloro-11-(1-piperazinyl)dibenz[b.f][1,4]oxazepine Amoxan Amoxapine Asendin Asendis CL 67772 CL-67772 Defanyl Demolox Moxadil
MDL Number	MFCD00069210
PubChem Substance ID	181085854
EC Number	237-867-1
Merck Number	576
Chemical Name Translation	阿莫沙平
Wiswesser Line Notation	T C676 BO INJ MG J- DT6M DNTJ
Beilstein Registry Number	0832057

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分类

Pharmaceuticals
{SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Diversification Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmission (Obesity), Neurotransmitters, Wyeth, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 肥胖研究, 蛋白质及衍生物
{SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Biogenic Amine Transport Inhibitors,

产品应用

Antidepressant.

安全信息

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSHQ4025500

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 70 mg/kg/3W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/ye

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Cardiac - pulse rate increase, without fall in BP
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   250,1069,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4286 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 385 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1852,1971

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P308+P311
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P405 Store locked up. 上锁保管。
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。