(2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid (2S)-2-氨基-4-(丁基磺酰基)丁酸
CAS 83730-53-4 MFCD00067000
化学结构图
SMILES: CCCCS(=N)(=O)CCC(N)C(O)=O
化学属性
| Mol. Formula | C8H18N2O3S |
|---|---|
| Mol. Weight | 222.31 |
| Melting Point | 224-226 |
| Density | 1.29 |
| Solubility | 溶于水(>25 mg/mL），酸性水溶液和1N 盐酸。 |
别名和识别编码
| Chemical Name | (2S)-2-amino-4-(butylsulfonimidoyl)butanoic acid |
|---|---|
| CAS Number | 83730-53-4 |
| Synonym | |
| MDL Number | MFCD00067000 |
| PubChem Substance ID | 24278263 |
| Beilstein Registry Number | 2367136 |
| Chemical Name Translation | (2S)-2-氨基-4-(丁基磺酰基)丁酸 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- B, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Chemopreventive Agents, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glutathione biosynthesis and Glu-Cys Ligase, Research Essentials
- {SNA} Chemopreventive Agents, Core Bioreagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Glutathione biosynthesis and Glu-Cys Ligase, Research Essentials, 生化试剂, 癌症研究, 细胞生物学, 酶、抑制剂和底物
- {SNA} Core Bioreagents, D to K,
产品应用
- 抑制γ谷氨酰半胱氨酸合成酶（在谷胱甘肽合成中的一个关键酶）。
相关文献及参考
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- 1. Broquist, H.P., Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants Nutr. Rev. 50 , 110-111, (1992)
- 2. Griffith, O.W., et al., Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis J. Biol. Chem. 257 , 13704-13712, (1982) 摘要
- Covey, T.M., et al., Alkylation Of The Tumor Suppressor PTEN Activates Akt And β-catenin Signaling: A Mechanism Linking Inflammation And Oxidative Stress With Cancer. PLoS ONE 5 , e13545, (2010) 摘要
- Chen, X., et al., Potential for selective modulation of glutathione in cancer chemotherapy. Chem. Biol. Interact. 111-112 , 263- 275, (1998)
安全信息
GHS Symbol
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lung DOSE/DURATION : 10 mmol/L REFERENCE : CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984- Volume(issue)/page/year: 7,249,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 3552 mg/kg SEX/DURATION : female 10-11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 44,251,1991
其他信息
- 溶解于水。
