(13S,13aR)-2,3,9,10-Tetramethoxy-13-Methyl-5,8,13,13A-Tetrahydro-6H-Isoquinolino[3,2-A]Isoquinoline (13S,13aR)-2,3,9,10-四甲氧基-13-甲基-5,8,13,13a-四氢-6h-异喹啉并[3,2-a]异喹啉
CAS 518-69-4 MFCD00065280
化学结构图
SMILES: COc1cc2c(cc1OC)C1C(C)c3ccc(OC)c(OC)c3CN1CC2
化学属性
| Mol. Formula | C₂₂H₂₇NO₄ |
|---|---|
| Mol. Weight | 369.45 |
| Melting Point | 134 - 136°C |
| Boiling Point |
别名和识别编码
| Chemical Name | (13S,13aR)-2,3,9,10-Tetramethoxy-13-Methyl-5,8,13,13A-Tetrahydro-6H-Isoquinolino[3,2-A]Isoquinoline |
|---|---|
| Synonym | (+)-Corydaline 13a-beta-Berbine, 2,3,9,10-tetramethoxy-13-alpha-methyl- 6H-Dibenzo(a,g)quinolizine, Berbine, 2,3,9,10-tetramethoxy-13-methyl- Corydalin Corydaline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {hazard_com} d-Corydaline |
| MDL Number | MFCD00065280 |
| Chemical Name Translation | (13S,13aR)-2,3,9,10-四甲氧基-13-甲基-5,8,13,13a-四氢-6h-异喹啉并[3,2-a]异喹啉 |
| CAS Number | 518-69-4 |
| PubChem Substance ID | 101301 |
| InChIKey | VRSRXLJTYQVOHC-YEJXKQKISA-N |
| Wiswesser Line Notation | T D6 B666 KN&TT&J C1 GO1 HO1 PO1 QO1 |
| Beilstein Registry Number | 0096972 |
| InChI | InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1 |
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相关文献及参考
- [2]. Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133.
- [3]. Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804.
- [1]. Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.
- [1]. Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22.
- [2]. Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133.
- [3]. Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 136 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946
