L-Lysine L-(+)-赖氨酸

CAS 56-87-1 MFCD00064433

化学结构图

56-87-1
SMILES:

化学属性

Mol. FormulaC6H14N2O2
Mol. Weight146.19
Melting Point215°C
Density1.125
Stability易吸潮
Appearance 赖氨酸为必需氨基酸，如缺乏则引起蛋白质代谢障碍及功能障碍，导致生长障碍。D-型赖氨酸无生理效果。 白色或近白色自由流动的结晶性粉末。几乎无臭。263~264℃熔化并分解。通常较稳定，高湿度下易结块，稍着色。相对湿度60%以下时稳定，60%以上则生成二水合物。与维生素C和维生素K3共存则着色。碱性条件及直接与还原糖存在下加热则分解。易溶于水(40g/100ml，35℃)，水溶液呈中性至微酸性，与磷酸、盐酸、氢氧化钠、离子交换树脂等一起加热，起外消旋作用。
SolubilitySoluble in water (300 g/l), and methanol (partly). Insoluble in diethyl ether, acetone, and ethanol.
Refractive index26 ° (C=2, 5mol/L HCl)
Boiling Point311.5°C at 760 mmHg

别名和识别编码

Chemical NameL-Lysine
CAS Number56-87-1
Alfabeta NameLYSINE L-
MDL NumberMFCD00064433
Synonym L-Lysine {LY} L-Lysine {} {LY} L-Lysine {} {} {LY} L-Lysine {} {} {} {LY} L-Lysine {} {} {} {} {LY} L-Lysine {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Lysine {} {} {} {} {} {} {}
PubChem Substance ID87572084
Beilstein Registry Number4,435
EC Number200-294-2
Chemical Name TranslationL-(+)-赖氨酸
Reaxys-RN1722531
Merck Number5636
LabNetwork Molecule IDLN00173246
Canonical SMILESN[C@@H](CCCCN)C(O)=O
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分类

  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acid Derivatives, Amino acids, Chemical Biology, Chemical Synthesis, Cichorium intybus (Chicory), Functional Foods, Ginkgo biloba, Humulus lupulus (Hops), Hypericum perforatum (St John's wort),

产品应用

  • A moderate serotonin antagonist and essential amino acid.

相关文献及参考

  • [2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193.
  • Merck:5636
  • Merck:5636 Beilstein:4,435
  • [1]. Santos AMD, et al. Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine. Acta Cir Bras. 2017 Apr;32(4):297-306.
  • [1]. Santos AMD, et al. Transitional metaplasia in intestinal epithelium of rats submitted to intestinal cystoplasty and treatment with L -lysine. Acta Cir Bras. 2017 Apr;32(4):297-306.
  • [2]. Al-Malki AL. Suppression of acute pancreatitis by L-lysine in mice. BMC Complement Altern Med. 2015 Jun 23;15:193.

安全信息

Warnings IRRITANT
WGK Germany1
RTECSOL5540000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
Hazard Codes Xi 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 372,75,1996

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 44 gm/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 74,93,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 138 gm/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 74,93,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 90450 mg/kg
SEX/DURATION            : female 10-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
R

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 72450 mg/kg
SEX/DURATION            : female 10-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   DTTIAF Deutsche Tieraerztliche Wochenschrift.  (Hanover, Fed. Rep. Ger.)
   V.1-77, 1893-1970.  Volume(issue)/page/year: 82,457,197

其他信息

  • MOL 文件:56-87-1.mol
  • 下游产品:L-赖氨酸盐酸盐 --> N-叔丁氧羰基-N'-(2-氯苄氧羰基)-L-赖氨酸 --> 赖诺普利 --> 盐酸赖氨酸 --> 1R,3R-反式菊酸 --> (S)-2,6-二叔丁氧羰基氨基己酸 --> L-盐酸组氨酸一水物 --> 1,5-二氨基戊烷 --> 饲料添加剂 --> 赖诺普利 --> L-赖氨酸-L-天冬氨酸盐
  • 用途三:营养增补剂。用于强化食品中的赖氨酸。植物蛋白质中一般赖氨酸含量较低。黑麦、米、玉米、花生粉等所含赖氨酸为限制氨基酸，小麦、芝麻、燕麦等所含赖氨酸为第一限制氨基酸。日本的强化规定用量(以L-赖氨酸计)：小麦粉、通心粉、速煮面等为150mg/100g；面包、饼干等为100mg/100g；速煮面50mg/100g。尚可用于蛋黄酱、乳粉、牛乳、方便食品等。 成人每日最小需要量(以L-赖氨酸计)：男性约0.8g，女性约0.4g，青年12～32mg/kg，幼儿180mg／
  • MSDS 信息:L-Lysine(56-87-1).msds
  • 方法二:一般用发酵法制取，有经由二氨基庚二酸的二步法，及从糖类直接制取的一步法。 合成法有以己内酰胺为原料及以糠醛为原料制取的二种方法。 由血粉、酪蛋白、脱脂大豆水解后，用离子交换树脂分离而得。
  • 参考质量标准:含量大于99.5%；比旋光度[α] 20 D +23°-+27°(0.5-2.0 mg/ml
  • 用途四:赖氨酸是人类和动物生长所必须的氨基酸之一，在输液、营养药品、食品和饲料添加剂等方面有重要用途。
  • 方法三:L-赖氨酸一般以L-赖氨酸盐酸盐[657-27-2]供应市场，游离的L-赖氨酸极易潮解，因具有游离氨基而易发黄变质，并有刺激腥味，难于长期保存。L-赖氨酸盐酸盐则比较稳定，不易潮解，便于保存。但L-赖氨酸在有些用途上的需求也在增加，例如多肽合成化学、生化研究、赖氨酸衍生物制备等。游离L-赖氨酸可由L-赖氨酸盐酸盐制备。
  • 图谱信息:L-赖氨酸(56-87-1)质谱(MS) L-赖氨酸(56-87-1)核磁图( 1 HNMR) L-赖氨酸(56-87-1)红外图谱(IR1) L-赖氨酸(56-87-1)核磁图(
  • 用途一:用作氨基酸类药
  • L-赖氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 L0129 L-(+)-赖氨酸 L-(+)-Lysine 25G 315元 2014/06/02 L0129 L-(+)-赖氨酸 L-(+)-Lysine 5G 80元 2010/06/21 303340050 L-赖氨酸 L-Lysine 98+% 5 GR 424元
  • FEMA:3847
  • 有吸湿性。极易溶于水，微溶于乙醇，几乎不溶于乙醚。加热至210℃变黑，224.5℃分解。
  • 用
  • Acros Organics:L-赖氨酸 L-Ly
  • 用途三:营养增补剂。
  • 图谱信息:L-赖氨酸(56-87-1)质谱(MS) L-赖氨酸(56-
  • Sigma Aldrich:56-87-1(sigmaaldrich)
  • 用途二:用于生化研究，医药上用于营养不良、食欲不振及发育不全等症状。
  • 图谱信息:L-赖氨酸(56-87-1)质谱(MS) L-赖氨酸(56-87-1)核磁图( 1 HNMR) L-赖氨酸(56-87-1)红外图谱(IR1) L-赖氨酸(56-87-1)核磁图( 13 C
  • Acros Org
  • 参考质量标准:含量大于99.5%；
  • 方法一:以红血球为原料，悬浮于硫酸溶液中，用氢氧化钙沉淀、水洗后，苦味酸溶解、结晶得产品。
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） l-赖氨酸 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Amino Acids 氨基酸
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. I-L - Alphabetical Listings
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Functional Foods - Nutrition Research
  4. Amino acids - Functional Foods
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium sativum (Garlic) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Hypericum perforatum (St John′s wort) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Lysine - Amino Acid Derivatives
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)