CAS 4350-09-8 MFCD00064341-Oxitriptan 5-羟基-L-色氨酸 TAO{mole}

Oxitriptan 5-羟基-L-色氨酸

CAS 4350-09-8 MFCD00064341

化学结构图

SMILES: N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O

化学属性

Mol. Formula	C11H12N2O3
Mol. Weight	220.22
Refractive index	n20/D 1.4850(lit.)
Density	0.902
Melting Point	270°C
TSCA	Yes
Flash Point	79.44°C
Solubility	Slightly soluble
Appearance	solid
Boiling Point	520.6°C at 760 mmHg

别名和识别编码

Chemical Name	L-2-Amino-3-(5-Hydroxyindolyl)Propionic Acid
CAS Number	4350-09-8
Alfabeta Name	HYDROXYTRYPTOPHAN L5---
MDL Number	MFCD00064341
Synonym	L-5-Hydroxytryptophan {LY} L-5-Hydroxytryptophan Oxitriptan Oxytryptophan Tryptophan, 5 Hydroxy Tryptophan, 5-Hydroxy- {} {LY} L-5-Hydroxytryptophan {} {} {LY} L-5-Hydroxytryptophan {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-5-Hydroxytryptophan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	439280
EC Number	224-411-1
Beilstein Registry Number	88200
Merck Number	4847
Chemical Name Translation	5-羟基-L-色氨酸
Reaxys-RN	88200
InChIKey	LDCYZAJDBXYCGN-VIFPVBQESA-N
Wiswesser Line Notation	T56 BMJ D1YZVQ GQ
LabNetwork Molecule ID	LN00173887
InChI	InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
Canonical SMILES	N[C@@H](CC1=CNC2=CC=C(O)C=C12)C(O)=O

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分类

{SNA} Amino acids, Chemical Biology, Chemical Synthesis, Functional Foods, Peptide Chemistry, Tryptophan Derivatives, Unnatural Amino Acids & Derivatives, 细胞生物学, 营养研究
Amino acids, Aromatic amino acid decarboxylase, L-, Bioactive Small Molecules, Biochemicals and Reagents, Catecholamine, Cell Biology, Cell Signaling and Neuroscience, Cofactor, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Functional Foods, H, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Neuroscience

安全信息

Warnings IRRITANT

RTECSYN7110000

WGK Germany3

GHS Symbol

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P310+P330
P301+P312
P301+P316
P301+P317
P302+P352
P303+P361+P353
P304+P312
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P317
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P370+P378
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H335 May cause respiratory irritation 可能导致呼吸道刺激

Hazard Codes 6.1 Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Packing GroupIII

UN Number 2811 UN 2811 6.1/PG 3

Risk Statements

R22 Harmful if swallowed 吞咽有害

Hazard Class6.1

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 6,307,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral -

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 91 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   69,523,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   69,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 6,356,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 27,85A,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 700 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 6,356,1975

TYPE OF TEST            : TDLo

其他信息

TCI Shanghai:5-羟基-L-色氨酸 5-Hydroxy-L-tryptophan,>;98.0%(T)(4350-09-8)
比旋光度:-32.5 ° (c=1,H2O on dry basis)
易溶于水。气微、味略带咸涩.
F:3-10
图谱信息:5-羟基色氨酸(4350-09-8)红外图谱(IR1) 5-羟基色氨酸(4350-09-8)核磁图( 1 HNMR) 5-羟基色氨酸(4350-09-8)质谱(MS) 5-羟基色氨酸(4350-09-8)红外图谱(IR2)
Alfa Aesar:L-5-羟基色氨酸水合物,98% L-5-Hydroxytryptophan hydrate, 98%(4350-09-8)
Acros Organics:L-5-羟色胺 L-5-Hydroxytryptophan, 99%(4350-09-8)
color:white
MOL 文件:4350-09-8.mol
5-羟基色氨酸价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 H0531 5-羟基-L-色氨酸 5-Hydroxy-L-tryptophan 1G 234元 2014/06/02 H0531 5-羟基-L-色氨酸 5-Hydroxy-L-tryptophan 5G 740元 2010/06/21 148290050 5-羟基色氨酸 L-5-Hydroxytryptophan 99% 5 GR 1255元
海关编码:29339990
Sigma Aldrich:4350-09-8(sigmaaldrich)
外观性质:浅灰白色精细粉末白色,易溶于水。气微、味略带咸涩.熔点：270°C
MSDS 信息:L-5-Hydroxytryptophan(4350-09-8).msds