CAS 302-95-4 MFCD00064139-Sodium deoxycholate 脱氧胆酸钠 TAO{mole}

Sodium deoxycholate 脱氧胆酸钠

CAS 302-95-4 MFCD00064139

化学结构图

SMILES: CC(CCC(=O)[O-])C1CCC2C3CCC4CC(O)CCC4(C)C3CC(O)C12C.[Na+]

化学属性

Mol. Formula	C24 H39 O4 . Na
Mol. Weight	414.5538
TSCA	Yes
Density	1.128
Melting Point	357-365 ℃
Solubility	Soluble in water (330 g/l) at 15 °C, DMSO, methanol, and ethanol (very slightly).
Stability	易吸潮

别名和识别编码

Chemical Name	Sodium deoxycholate
Synonym	(3-alpha,5-beta,12-alpha)-12-dihydroxy-cholan-24-oicacidmonosodiumsalt 12beta-Isomer Deoxycholic Acid 3α,12α-二羟-5β-胆烷酸钠盐 3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oicacisodiumsalt 3beta-Isomer Deoxycholic Acid 3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt 3α,12α-二羟-5β-胆烷酸钠盐去氧胆酸钠盐脱氧胆酸钠盐 5-BETA-CHOLANIC ACID-3-ALPHA, 12-ALPHA-DIOL SODIUM SALT 5alpha-Isomer Deoxycholic Acid 7-DEOXYCHOLIC ACID SODIUM SALT 7-Deoxycholic acid sodium salt CHOLEIC ACID SODIUM SALT Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, Choleic Acid DEOXYCHOLIC ACID NA-SALT DESOXYCHOLIC ACID SODIUM SALT Deoxycholate Deoxycholate, Sodium Deoxycholic Acid Deoxycholic Acid, 12beta Isomer
CAS Number	302-95-4
PubChem Substance ID	23668196
EC Number	206-132-7
Beilstein Registry Number	3581950
MDL Number	MFCD00064139
Reaxys-RN	6472196
Merck Number	2899
Chemical Name Translation	脱氧胆酸钠
InChIKey	FHHPUSMSKHSNKW-SMOYURAASA-M
Wiswesser Line Notation	L E5 B666TJ A1 DQ E1 FY1&2VO OQ &-NA-
LabNetwork Molecule ID	LN01740949
Canonical SMILES	C[C@@]1([C@@]2([H])[C@H](C)CCC(O[Na])=O)[C@](CC2)([H])[C@@](CC[C@@]3([H])[C@@]4(CC[C@@H](O)C3)C)([H])[C@]4([H])C[C@@H]1O
InChI	InChI=1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

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分类

{SNA} anionic
{SNA} Anionic Detergents, Antigen-Vaccine Preparation, Bile Salts, Bile acids and Derivatives, Cell Culture, Cell Lysis Reagents, Core Biore
{SNA} Anionic Detergents, Antigen-Vaccine Preparation, Bile Salts, Bile acids and Derivatives, Biochemicals and Reagents, Cell Culture, Core Bioreagents, Detergents, Detergents N to Z, Detergents by Applications, Diagnostic Applications, Drug Delivery-Liposomes, Electrophoresis Chromatography, Lipids, Membrane Protein Solubilization, Molecular Biology, Research Essentials, Sterol Lipids

产品应用

An ionic detergent for the solubilization of membrane-bound proteins.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn

Hazard statements

H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSFZ2250000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P301+P317
P302+P352
P304+P340
P305+P351+P338
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P317
P337+P317
P362+P364
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R37 Irritating to respiratory system 刺激呼吸道

Storage condition +4°C 2-8°C 2-8°C, sealed storage, away from moisture 2-8°C储存 4℃ Store at RT. 储存温度2-8℃ 储存温度2-8℃,充氩保存

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,323,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 123 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2430 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 15 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - other changes
REFERENCE :
   ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin.  (Berlin, Fed.
   Rep. Ger.)  V.1-139, 1913-65.  For publisher informa

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 960 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 93,101,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 pph/3H
REFERENCE :
   CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology.  (Cold Spring
   Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724)  V.1-    1933-
   Volume(issue)/page/year: 12,256,1947

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 28,504,1982

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 25 mg/L
REFERENCE :
   NUCADQ Nutrition and Cancer.  (Franklin Institute Press, POB 2266,
   Phildelphia, PA 19103) V.1-    1978-  Volume(issue)/page/year: 16,227,1991

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Rectal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 10 umol/kg
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   75,29,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,45,1969

其他信息

MOL 文件:302-95-4.mol
脱氧胆酸钠价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 69022780 脱氧胆酸钠;去氧胆酸钠 10g 62元 2011/04/16 C0316 脱氧胆酸钠 Sodium Deoxycholate 25G 540元 2011/04/16 D1820 脱氧胆酸钠[用于电泳] Sodium Deoxycholate [for Electrophoresis] 25G 1010元
Acros Organics:脱氧胆酸钠 Deoxycholic acid, sodium salt, extra pure, 99%(302-95-4)
类似胆汁气味。有强烈苦味。易吸湿。易溶于水，微溶于无水醇，不溶于醚。水中溶解度:330 g/L (15°C)
用途一:阴离子去垢剂，用于抽提膜受体和其它的膜蛋白，也用于核分离。也用于配制细菌培养基，代替脑磷脂作胆固醇絮状试验。
MSDS 信息:Sodium deoxycholate(302-95-4).msds
图谱信息:脱氧胆酸钠(302-95-4)核磁图( 13 CNMR) 脱氧胆酸钠(302-95-4)红外图谱(IR2) 脱氧胆酸钠(302-95-4)红外图谱(IR1)
比旋光度:44 ° (c=2, H2O)
F:3-10
TCI Shanghai:脱氧胆酸钠[用于电泳] Sodium Deoxycholate [for Electrophoresis],>;98.0%(T)(302-95-4)
外观性质:白色结晶性粉末。类似胆汁气味。有强烈苦味。易吸湿。易溶于水，微溶于无水醇，不溶于醚。水中溶解度:330 g/L (15°C)比旋光度[α]20D 42 ° (C=2, H2O) 熔点：360 °C
Sodium deoxycholate is an ionic detergent for the solubilization of membrane-bound proteins. Deoxycholic Acid, Sodium Salt is reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of β-catenin signaling (effective concentration 5-50 μM).
海关编码:29181930
Sigma Aldrich:302-95-4(sigmaaldrich)