CAS 1220-83-3 MFCD00063466-4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide 4-氨基-N-(6-甲氧基嘧啶-4-基)苯磺酰胺 TAO{mole}

4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide 4-氨基-N-(6-甲氧基嘧啶-4-基)苯磺酰胺

CAS 1220-83-3 MFCD00063466

化学结构图

SMILES: COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1

化学属性

Mol. Formula	C11H12N4O3S
Mol. Weight	280.30
Melting Point	203-206°C
Appearance	白色或类白色结晶性粉末,无臭，无味。熔点204-206℃。极微溶于水和乙醇，易溶于稀酸、稀碱液。遇光易被氧化而渐变暗。

别名和识别编码

Chemical Name	4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
CAS Number	1220-83-3
Alfabeta Name	AMINOMETHOXYPYRIMIDINYLBENZENESULFONAMIDE N464()-------
MDL Number	MFCD00063466
Synonym	Sulfamonomethoxine {TRC} ######## 4-AMINO-N-[6-METHOXY-4-PYRIMIDINYL]BENZENESULFONAMIDE 4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide 4-Amino-N-(6-methoxy-pyrimidin-4-yl)-benzenesulfonamide AKOS B014359 Benzenesulfonamide, 4-amino-N-(6-methoxy-4-pyrimidinyl)- DJ-1550 ICI 32525 N-(6-甲氧基-4-嘧啶基)-4-氨基苯磺酰胺 Ro 4-3476 SULAMONOMETHOXINE SULFAMONOMETHOXINE Sulfamomomethoxine(sodium) Sulfamomonethoxine Sulfamonomethoxin daimeton dj-1550 ici32525 ro4-3476 如磺胺间甲氧嘧啶泰灭净磺胺六甲氧嘧啶磺胺间甲氧嘧啶,
PubChem Substance ID	87577958
Beilstein Registry Number	621128
Chemical Name Translation	4-氨基-N-(6-甲氧基嘧啶-4-基)苯磺酰胺
Reaxys-RN	621128
Wiswesser Line Notation	T6N CNJ DO1 FMSWR DZ
LabNetwork Molecule ID	LN00158705
InChI	InChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
Canonical SMILES	O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC)=C2)=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim

安全信息

Warnings IRRITANT

WGK Germany2

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P350
P302+P352
P302+P352+P333+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P333+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSWP0550000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xi

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Storage condition 2-8°C {TCI} 0-10 0-10°C 0-6°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4680 mg/

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - food intake (animal)
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,133,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - irritability
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Ya

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1010 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,391,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >7 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - irritability
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 9

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 13,7,1973

其他信息

磺胺间甲氧嘧啶价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 S0592 磺胺间甲氧嘧啶 Sulfamonomethoxine 5G 506元 2014/06/02 S0592 磺胺间甲氧嘧啶 Sulfamonomethoxine 25G 1290元
用途一:磺胺类药，用于溶血性链球菌、肺炎球菌及脑膜炎球菌等感染
上游原料:丙二酸二乙酯 --> 三氯乙烯 --> 丙二酸二丁酯
参考质量标准:参见《中国兽药典》1990年版含量(干基)/% ≥99.0 氯化物(CI - )/% ≤0.01 干燥失重/% ≤0.5 灼烧残渣/% ≤0.1 重金属/% ≤0.002
方法一:由丙二酸二丁酯经环合、缩合、醚化、酸化等步骤制得。
用途二:作为广谱抗菌剂，对溶血性链球菌、肺炎球菌、大肠杆菌均有效。主要用于治疗尿路感染、呼吸道感染，对动物支原体、工形体和球虫病等也有杀灭作用。
Sigma Aldrich:1220-83-3(sigmaaldrich)
MOL 文件:1220-83-3.mol