Puromycin aminonucleoside 3'-氨基-3'-脱氧-N,N-二甲基腺苷
CAS 58-60-6 MFCD00063462
化学结构图
SMILES: CN(C)c1ncnc2c1ncn2C1OC(CO)C(N)C1O
化学属性
| Mol. Formula | C12H18N6O3 |
|---|---|
| Mol. Weight | 294 |
| Density | 1.7 |
| Solubility | Soluble in water (10 mg/ml) |
别名和识别编码
| Chemical Name | Puromycin aminonucleoside |
|---|---|
| MDL Number | MFCD00063462 |
| CAS Number | 58-60-6 |
| Synonym | 3′-Amino-3′-deoxy-N6,N6-dimethyladenosine 氨基核苷嘌呤霉素 3'-Amino-3'-deoxy-N6,N6-dimethyladenosine Stylomycin aminonucleoside Aminonucleoside 博罗霉素氨基核苷 Puromycin aminonucleoside Aminonucleoside puromycin SAN |
| PubChem Substance ID | 6020 |
| Beilstein Registry Number | 93902 |
| EC Number | 200-388-3 |
| Chemical Name Translation | 3'-氨基-3'-脱氧-N,N-二甲基腺苷 |
| InChIKey | RYSMHWILUNYBFW-GRIPGOBMSA-N |
| Wiswesser Line Notation | T56 BN DN FN HNJ IN1&1 D- BT5OTJ CQ DZ E1Q |
| LabNetwork Molecule ID | LN01327490 |
| InChI | InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7-,9-,12-/m1/s1 |
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分类
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Biochemicals and Reagents, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity
- {SNA} Antibacterial, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Genetic Marker Selection, Interferes with Protein Synthesis, L - Z, Mechanism of Action, Spectrum of Activity, 抗生素, 生化试剂
- {SNA} Antibacterial,
产品应用
- The aminonucleoside portion of the antibiotic puromycin.
相关文献及参考
- [2]. Wada T, et al. Prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. J Am Soc Nephrol. 2005 Sep;16(9):2615-25.
- [3]. Gong W, et al. Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury. Am J Physiol Renal Physiol. 2019 May 1;316(5):F906-F913.
- [4]. Xia L, et al. Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleosidenephrotoxicity. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1307-13.
- [5]. Kawakami H, et al. Dynamics of absolute amount of nephrin in a single podocyte in puromycin aminonucleoside nephrosis rats calculated by quantitative glomerular proteomics approach with selected reaction monitoring mode. Nephrol Dial Transplant. 2012 Apr;
- [6]. Nosaka K, et al. An adenosine deaminase inhibitor prevents puromycin aminonucleoside nephrotoxicity. Free Radic Biol M
安全信息
GHS Symbol
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- R48/22
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lung DOSE/DURATION : 6 mg/L REFERENCE : JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 81,71,1973
TYPE OF TEST : DNA inhibition ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 83 mg/kg REFERENCE : JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 30,13,1966
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lung DOSE/DURATION : 6 mg/L REFERENCE : JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 81,71,1973
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lung DOSE/DURATION : 100 mg/L REFERENCE : JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 81,71,1973
TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 83 mg/kg REFERENCE : JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 30,13,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 105 ug/kg SEX/DURATION : female 5-11 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 195,1209,1962
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 45 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964- Volume(issue)/page/year: 3,344,1966
其他信息
- Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability
