CAS 1088-11-5 MFCD00063440-Nordazepam 去甲安定 TAO{mole}

Nordazepam 去甲安定

CAS 1088-11-5 MFCD00063440

化学结构图

SMILES: O=C1CN=C(C2CCCCC2)c2cc(Cl)ccc2N1

化学属性

Mol. Formula	C15H11ClN2O
Mol. Weight	270.73

别名和识别编码

Chemical Name	Desmethyl Diazepam
CAS Number	1088-11-5
Synonym	1-Demethyldiazepam 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl- 7-Chloro-1,3-dihydro-5-phenyl- 7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Calmday DMDZ Dealkylprazepam Demethyldiazepam Deoxydemoxepam Desalkylprazepam Desmethyldiazepam Madar N Desalkylhalazepam N Descyclopropylmethyl Prazepam N Descyclopropylmethylprazepam N Destrifluoroethylhalazepam N-Demethyldiazepam N-Deoxydemoxapam N-Desalkylhalazepam N-Descyclopropylmethyl-Prazepam N-Descyclopropylmethylprazepam N-Desmethyldiazepam N-Destrifluoroethylhalazepam NDD Nordaz Nordazepam Nordiazepam Nordiazepam solution Nordiazepam; Desmethyldiazepam; 7-Chloro
PubChem Substance ID	2997
EC Number	214-123-4
MDL Number	MFCD00063440
Wiswesser Line Notation	T67 GMV JN IHJ CG KR
Beilstein Registry Number	0751823
Chemical Name Translation	去甲安定
InChI	InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

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分类

Alphabetic, Analytical Standards, Analytical/Chromatography, Benzodiazepin Analoga Structure, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, D, D-DIF, DA - DH, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Neurobiology, Neuroscience, Pharmacologicals
{SNA} Alphabetic, Analytical Standards, Analytical/Chromatography, D, DA - DH

产品应用

The primary metabolite of Diazepam. A ligand for the GABAA receptor benzodiazepine modulatory site. Anxiolytic.

安全信息

GHS Symbol

WGK Germany1

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H331 Toxic if inhaled 吸入中毒
H370 Causes damage to organs 导致器官损伤

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes Xn

RTECSDF1750000

Signal word Warning Danger

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P312
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   16,311,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 670 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   4,467,1968

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 15,241,1978

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Ey

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri K

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 57 nmol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   38,4478,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   25,453,1973