2H,1,4-Benzodiazepin-2-one,7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- 劳拉西泮
CAS 846-49-1 MFCD00063406
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资金保障
专业采购外包团队在线服务
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分类
- Approved Therapeutics/Drug Candidates, Baxter, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Neurobiology, Neuroscience, Pharmacologicals
- {SNA} Approved Therapeutics/Drug Candidates, Baxter, Benzodiazepines and Anxiolytics, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, L, Neurobiology, Neuroscience, Pharmacologicals
产品应用
- An anxiolytic, and anticonvulsant.
相关文献及参考
- Rutgers, G., et al.: Anal. Profiles Drug Subs., 9, 397 (1980),
- Korkmaz, S., et al.: Eur. Neuropsychopharmacol., 8, 175 (1998),
- D?Onofrio, G., et al.: N. Engl. J. Med., 340, 915 (1999),
- Korkmaz, S., et al. Eur. Neuropsychopharmacol. 8 , 175, (1998) 摘要
- Merck 14 ,5579
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
- R11 Highly flammable 非常易燃
- R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >25 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - nausea or vomiting REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,1065,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1850 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-c
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1(1
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 1208 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - pleural thickening REFERENCE : PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 11,32,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 242
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 16 mg/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral REFERENCE : NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 30,53,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 14 mg/kg SEX/DURATION : female 14-20 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - behavioral REFERENCE : PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 51,721,1995
TYPE OF TEST : TDLo - Lowest published toxic dos
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 2420 ug/kg SEX/DURATION : female 36-39 week(s) after conception lactating female 2 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - other neonatal measures or effects REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 282,1106,1981
TYPE OF
其他信息
- Sigma Aldrich:846-49-1(sigmaaldrich)
- 可燃性危险特性:热分解排出有毒氮氧化物, 氯化物烟雾
- 类别:有毒物质
- 毒性分级:中毒
- 储运特性:库房低温通风干燥
- 急性毒性:口服-大鼠 LD50: 4500 毫克/公斤; 口服-小鼠 LD50: 1850 毫克/公斤
- 上游原料:氯乙酰氯 --> 2,5-二氯二苯甲酮
- MSDS 信息:7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one(846-49-1).msds
- 方法一:2-氨基2',5-二氯二苯甲酮依次与羟胺、氯乙酰氯、甲胺反应,然后与乙酐反应制得3-醋酸基-7-氯-5-(邻氯苯)-1,3-二氢-2H-1,4-苯并二氮-2-酮,再用氢氧化钠溶液处理,得到白色固体沉淀,过滤,水洗,用乙醇结晶,即得氯羟安定。
- 灭火剂:水,二氧化碳, 泡沫, 干粉
- 用途一:该品具有镇静、肌肉松弛和抗惊厥作用。催眠作用较强,可持续8小时。
- MOL 文件:846-49-1.mol