CAS 1098-60-8 MFCD00058103-Triflupromazine Hydrochloride 三氟丙嗪盐酸盐 TAO{mole}

Triflupromazine Hydrochloride 三氟丙嗪盐酸盐

CAS 1098-60-8 MFCD00058103

化学结构图

SMILES: CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21.Cl

化学属性

Mol. Formula	C18H19F3N2S.ClH
Mol. Weight	388.91

别名和识别编码

Chemical Name	Triflupromazine Hydrochloride
MDL Number	MFCD00058103
CAS Number	1098-60-8
PubChem Substance ID	24870481
Beilstein Registry Number	3801519
EC Number	214-149-6
Synonym	N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine monohydrochloride 三氟丙嗪盐酸盐 Trifluopromazine hydrochloride Triflupromazine hydrochloride 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, 10-(3-Dimethylaminopropyl)-2-(trifluoromethyl)phenothiazine hydrochloride Vesprin hydrochloride
Chemical Name Translation	三氟丙嗪盐酸盐
Wiswesser Line Notation	T C666 BN ISJ B3N1&1 EXFFF
LabNetwork Molecule ID	LN01302213

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安全信息

RTECSSO8925000

GHS Symbol

Precautionary statements

P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。

Hazard statements

H332 Harmful if inhaled 吸入有害
H312 Harmful in contact with skin 皮肤接触有害
H301 Toxic if swallowed 吞食有毒

WGK Germany3

Signal word Danger

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Hazard Codes Xn

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 254 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,56,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,56,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 102 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - ataxia
REFERENCE :
   MTHEA8 Monographs on Therapy.  (The Squibb Institute for Medical Research,
   New Brunswick, NJ)  Volume(issue)/page/year: 2,214,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 17 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory obstruction
   Blood - hemorrhage
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 127,55,1959

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES O

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 10 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 8,617,1970

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 20 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 8,617,1970