CAS 7232-21-5 MFCD00058011-Metoclopramide Hydrochloride 甲氧氯普胺盐酸盐 TAO{mole}

Metoclopramide Hydrochloride 甲氧氯普胺盐酸盐

CAS 7232-21-5 MFCD00058011

化学结构图

SMILES: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC.Cl

化学属性

Mol. Formula	C14H22ClN3O2·HCl
Mol. Weight	336
Density	1.422

别名和识别编码

Chemical Name	Metoclopramide Hydrochloride
MDL Number	MFCD00058011
CAS Number	7232-21-5
EC Number	230-634-5
Beilstein Registry Number	2384789
PubChem Substance ID	23659
Synonym	甲氧氯普胺盐酸盐 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-, 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide hydrochloride
Chemical Name Translation	甲氧氯普胺盐酸盐
InChIKey	RVFUNJWWXKCWNS-UHFFFAOYSA-N
Wiswesser Line Notation	2N2&2MVR DZ CG FO1 &GH
InChI	InChI=1S/C14H22ClN3O2.ClH/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3;/h8-9H,4-7,16H2,1-3H3,(H,17,19);1H
LabNetwork Molecule ID	LN01299785

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安全信息

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338

Hazard statements

H302 Harmful if swallowed 吞食有害

RTECSBZ3325000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   BJCPAT British Journal of Clinical Practice.  (Medical News Group, 1 Bedford
   St., London WC2E 9HD, UK)  V.10(10)-    1956- Volum

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1161 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   SMJOAV Southern Medical Journal.  (Southern Medical Assoc., POB 2446,
   Birmingham, AL 35205) V.1-    1908-  Volume(issue)/page/year: 76,817,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg/3D-I
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CMAJAX Canadian Medical Association Journal.  (Canadian Medical Assoc., POB
   8650, Ottawa, ON K1G 0G8, Canada)  V.1-    1911-  Volume(issue)/page/year:
   126,23,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 400 ug/kg/16H-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AACRAT Anesthesia and Analgesia (New York).  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.36-    1957-
   Volume(issue)/page/year: 66,274,1987